ArticleChildren (Basel, Switzerland)2019
Oxygenation and Hemodynamics during Chest Compressions in a Lamb Model of Perinatal Asphyxia Induced Cardiac Arrest.
Article in Children (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- RECOVER Guidelines: Newborn Resuscitation in Dogs and Cats. Evidence and Knowledge Gap Analysis With Treatment Recommendations.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2025Pooled it
- Neonatal resuscitation for bradycardia (HR < 60 bpm)-an alternate approach using an ovine model.Pediatric research · 2026Article
- The Role of 100% Oxygen in the Resuscitation and Neurologic Recovery of Neonates Born with Perinatal Depression and Arrested Circulation.The Journal of pediatrics · 2026Article
- Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study.Pediatric research · 2026Article
- The Latest in Resuscitation Research: Highlights From the 2023 American Heart Association's Resuscitation Science Symposium.Journal of the American Heart Association · 2025Article
- Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- Oxygen saturation targets in neonatal care: A narrative review.Early human development · 2024Review
- Neonatal resuscitation with continuous chest compressions and high frequency percussive ventilation in preterm lambs.Pediatric research · 2024Article
- Optimal oxygen use in neonatal advanced cardiopulmonary resuscitation-a literature review.Pediatric medicine (Hong Kong, China) · 2023Article
- Randomized Trial of 21% versus 100% Oxygen during Chest Compressions Followed by Gradual versus Abrupt Oxygen Titration after Return of Spontaneous Circulation in Neonatal Lambs.Children (Basel, Switzerland) · 2023Article
- Physiology of neonatal resuscitation: Giant strides with small breaths.Seminars in perinatology · 2022Review
- Neonatal chest compressions: time to act.Pediatric research · 2021Article
- Excess cerebral oxygen delivery follows return of spontaneous circulation in near-term asphyxiated lambs.Scientific reports · 2020Article
- Chest Compressions for Bradycardia during Neonatal Resuscitation-Do We Have Evidence?Children (Basel, Switzerland) · 2019Review
- Is Supplemental Oxygen Needed in Cardiac Compression?-The Influence of Oxygen on Cerebral Perfusion in Severely Asphyxiated Neonates With Bradycardia or Cardiac Asystole.Frontiers in pediatrics · 2019Review
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
The current guidelines recommend the use of 100% O₂ during resuscitation of a neonate requiring chest compressions (CC). Studies comparing 21% and 100% O₂ during CC were conducted in postnatal models and have not shown a difference in incidence or timing of return of spontaneous circulation (ROSC). The objective of this study is to evaluate systemic oxygenation and oxygen delivery to the brain during CC in an ovine model of perinatal asphyxial arrest induced by umbilical cord occlusion. Pulseless cardiac arrest was induced by umbilical cord occlusion in 22 lambs. After 5 min of asystole, lambs were resuscitated with 21% O₂ as per Neonatal Resuscitation Program (NRP) guidelines. At the onset of CC, inspired O₂ was either increased to 100% O₂ (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.