ReviewChildren (Basel, Switzerland)2019
Epinephrine in Neonatal Resuscitation.
Review in Children (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- Efficacy of laryngeal mask epinephrine in neonatal resuscitation; an ovine study.Pediatric research · 2026Article
- Dose-Related Pharmacokinetic and Pharmacodynamic Effects of Intramuscular Epinephrine in Healthy Neonatal Piglets.Children (Basel, Switzerland) · 2025Article
- Resuscitation after birth and beyond in the neonatal intensive care unit: NRP or PALS?Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Evaluating the efficacy of endotracheal and intranasal epinephrine administration in severely asphyxic bradycardic newborn lambs: a randomised preclinical study.Archives of disease in childhood. Fetal and neonatal edition · 2025Article
- Effect of vasopressin on brain and cardiac tissue during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets.Resuscitation plus · 2025Article
- Vasopressin versus epinephrine during cardiopulmonary resuscitation of asphyxiated newborns: A study protocol for a prospective, cluster, open label, single-center, randomized controlled phase 2 trial - The VERSE-Trial.Resuscitation plus · 2023Article
- Vasopressin versus epinephrine during neonatal cardiopulmonary resuscitation of asphyxiated post-transitional piglets.Resuscitation plus · 2023Article
- Optimal oxygen use in neonatal advanced cardiopulmonary resuscitation-a literature review.Pediatric medicine (Hong Kong, China) · 2023Article
- Randomized Trial of 21% versus 100% Oxygen during Chest Compressions Followed by Gradual versus Abrupt Oxygen Titration after Return of Spontaneous Circulation in Neonatal Lambs.Children (Basel, Switzerland) · 2023Article
- Technical feasibility of multimodal imaging in neonatal hypoxic-ischemic encephalopathy from an ovine model to a human case series.Frontiers in pediatrics · 2023Article
- Inadequate Bioavailability of Intramuscular Epinephrine in a Neonatal Asphyxia Model.Frontiers in pediatrics · 2022Article
- Randomised trial of epinephrine dose and flush volume in term newborn lambs.Archives of disease in childhood. Fetal and neonatal edition · 2021Article
- Singapore Neonatal Resuscitation Guidelines 2021.Singapore medical journal · 2021Article
- What is the optimal initial dose of epinephrine during neonatal resuscitation in the delivery room?Journal of perinatology : official journal of the California Perinatal Association · 2021Review
- Effect of a Larger Flush Volume on Bioavailability and Efficacy of Umbilical Venous Epinephrine during Neonatal Resuscitation in Ovine Asphyxial Arrest.Children (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Epinephrine is the only medication recommended by the International Liaison Committee on Resuscitation for use in newborn resuscitation. Strong evidence from large clinical trials is lacking owing to the infrequent use of epinephrine during neonatal resuscitation. Current recommendations are weak as they are extrapolated from animal models or pediatric and adult studies that do not adequately depict the transitioning circulation and fluid-filled lungs of the newborn in the delivery room. Many gaps in knowledge including the optimal dosing, best route and timing of epinephrine administration warrant further studies. Experiments on a well-established ovine model of perinatal asphyxial cardiac arrest closely mimicking the newborn infant provide important information that can guide future clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.