ArticleThe American journal of surgical pathology2019
Intraductal Oncocytic Papillary Neoplasms: Clinical-Pathologic Characterization of 24 Cases, With An Emphasis on Associated Invasive Carcinomas.
Article in The American journal of surgical pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Pancreatic ductal adenocarcinoma and its subtypes: clinical relevance of histopathology and molecular characterization, integrating the key updates of the 2026 WHO classification.Virchows Archiv : an international journal of pathology · 2026Review
- Benign Biliary Tumors and Precursor Neoplasms: An Updated Clinicopathological and Molecular Review Based on the 2026 WHO Classification.Biomedicines · 2026Review
- When Clinical Suspicion Overrides Benign Biopsy: Invasive Pancreatic Intraductal Oncocytic Papillary Neoplasm With Concurrent Neuroendocrine Tumor.ACG case reports journal · 2026Article
- A case of intraductal oncocytic papillary neoplasm treated with distal pancreatectomy.International journal of surgery case reports · 2026Article
- Metastasis of Pancreatic Intraductal Oncocytic Papillary Neoplasm to the Ovaries.Case reports in gastrointestinal medicine · 2026Article
- A rare cystic and papillary variant of acinar cell carcinoma with liver metastasis and molecular analysis.Virchows Archiv : an international journal of pathology · 2025Article
- Incidence and Outcomes of Intraductal Oncocytic Papillary Neoplasm-Derived Pancreatic Cancer Compared with Tubular and Colloid Intraductal Papillary Mucinous Neoplasm-Derived Pancreatic Cancer: An International Multicenter Retrospective Study.Annals of surgical oncology · 2025Observational
- Deciphering pancreatobiliary intraductal oncocytic papillary neoplasms: integrative analysis of histomorphologic patterns, immunophenotypic markers, and emerging molecular biomarkers.World journal of surgical oncology · 2025Review
- Rare pancreatic cystic neoplasms: A pictorial review.European journal of radiology open · 2025Article
- Laparoscopic management of intraductal oncocytic papillary neoplasm of the pancreas: Two case reports and review of literature.World journal of gastrointestinal surgery · 2025Article
- Comparison of Ampullary and Pancreatic Adenocarcinomas: Smaller Invasion, Common Adenomatous Components, Resectability, and Histology are Factors for Improved Survival for Patients with Ampullary Adenocarcinoma.Annals of surgical oncology · 2025Article
- MRI findings of pancreatic intraductal oncocytic papillary neoplasm: three case reports and review of literature.Frontiers in medicine · 2025Article
- Article
- Early Cancerous Lesions of the Pancreas and Ampulla: Current Concepts and Challenges.Gastroenterology clinics of North America · 2024Review
- Non-invasive intraductal oncocytic papillary neoplasm forming a protruding lesion toward the duodenum from the accessory papilla: a case report.Surgical case reports · 2024Article
- A missed case of intraductal oncocytic papillary neoplasm associated with missed stones in extrahepatic bile duct: a case report.Frontiers in oncology · 2024Article
- Pathologic Features of Primary Pancreatic Malignancies.Cancer treatment and research · 2024Review
- Improving the prognosis of pancreatic cancer: insights from epidemiology, genomic alterations, and therapeutic challenges.Frontiers of medicine · 2023Review
- Article
- Preoperatively diagnosed intraductal oncocytic papillary neoplasm of the pancreas with prominent invasion: a case report.Clinical journal of gastroenterology · 2023Article
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Abstract
backgroundIntraductal oncocytic papillary neoplasm (IOPN) of the pancreas is a rare tumor. Recent molecular data indicate that it is distinct from other intraductal neoplasms; however, its clinicopathologic characteristics, especially the frequency/significance of an invasive carcinoma component, and biologic behavior remain to be fully defined.
designClinicopathologic characteristics and survival of 24 IOPNs were analyzed. By definition, all tumors exhibited intraductal growth and oncocytic morphology.
resultsThe female:male ratio was 1.7, and mean age was 59. In 44% of the patients, the IOPN was discovered incidentally; however, the working diagnosis was "ductal adenocarcinoma" in 42%. Fourteen IOPNs occurred in the head of the pancreas. The median tumor size was 4.5 cm. The tumors often grew along adjacent benign ducts, mimicking invasion, but only 29% exhibited unequivocal invasive carcinoma, mostly in the form of microscopic foci (pT1a=4, pT1b=1, pT2=2), and only 6% had lymph node metastasis. Invasive carcinoma was predominantly composed of small tubular units lined by oncocytic cells, or individual oncocytic cells infiltrating the periductal stroma. Follow-up information was available for 18 patients (median=6.8 y). No patients died from the disease, and the overall 10-year survival was 94%. Patients with invasive carcinoma trended toward a lower 5-year recurrence-free survival than those with noninvasive IOPNs (66% vs. 93%, P=0.066), but overall survival was not impacted by the presence of invasion (P=0.38).
conclusionsIOPN is a distinct tumor type in the pancreas. Despite its morphologic complexity and often extensive pagetoid spread to adjacent ducts, conventional invasive carcinoma is seen in only 29% and usually as microscopic foci. Thus, it is not surprising that IOPN exhibits indolent behavior even when invasion is present.
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