ArticleNeuroepidemiology2019
Incident Mobility Disability, Mild Cognitive Impairment, and Mortality in Community-Dwelling Older Adults.
Article in Neuroepidemiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 33 citations in OpenAlex.
- Does an Innovative PT Program Targeting Mobility Benefit Veterans With Executive Function Deficit?Journal of the American Geriatrics Society · 2026Trial
- Effect of Electrical Muscle Stimulation and Resistance Exercise Intervention on Physical and Brain Function in Middle-Aged and Older Women.International journal of environmental research and public health · 2022Trial
- Longitudinal associations of sarcopenia and biological age acceleration with rate of cognitive decline.BMC public health · 2026Article
- Net effects of correlated determinants of health among U.S. older adults.BMC geriatrics · 2025Article
- Group Chair-Stand Exercise and Cognitive Recovery in Sarcopenic Stroke Patients.Annals of geriatric medicine and research · 2025Observational
- A scoping review and synthesis of the literature on the relation between mobility impairment and cognitive impairment.Disability and rehabilitation · 2025Article
- Association between high plasma p-tau181 level and gait changes in patients with mild cognitive impairment.Scientific reports · 2025Article
- Temporal Sequence of Incident Mild Cognitive Impairment, Incident Parkinsonism, and Risk of Death in Unimpaired Community-Dwelling Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Article
- Relation of Motor Impairments to Neuropathologic Changes of Limbic-Predominant Age-Related TDP-43 Encephalopathy in Older Adults.Neurology · 2023Article
- Cognition and Mortality Risk Among Midlife and Older Americans.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Transitions Between Mild Cognitive Impairment, Dementia, and Mortality: The Importance of Olfaction.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Review
- Social Engagement and All-Cause Mortality: A Focus on Participants of the Minority Aging Research Study.American journal of preventive medicine · 2022Article
- Mixed Neuropathologies, Neural Motor Resilience and Target Discovery for Therapies of Late-Life Motor Impairment.Frontiers in human neuroscience · 2022Article
- Risk Models Based on Non-Cognitive Measures May Identify Presymptomatic Alzheimer's Disease.Journal of Alzheimer's disease : JAD · 2022Article
- Sarcopenia is associated with incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline.Journal of the American Geriatrics Society · 2021Article
- Chronic Posttraumatic Stress Disorder and Comorbid Cognitive and Physical Impairments in World Trade Center Responders.Journal of traumatic stress · 2021Article
- Diverse Motor Performances Are Related to Incident Cognitive Impairment in Community-Dwelling Older Adults.Frontiers in aging neuroscience · 2021Article
- Incident mobility disability, parkinsonism, and mortality in community-dwelling older adults.PloS one · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND/
aimsMobility disability and mild cognitive impairment (MCI) are common in aging and both are associated with risk of death. This study tested the hypothesis that risk of death differs by the order in which mobility disability and MCI occurred.
methodsOne thousand two hundred and sixty-two community-dwelling older adults were unimpaired at baseline and followed annually. Mobility disability was based on measured gait speed, and MCI was based on cognitive performance tests. A multistate Cox model simultaneously examined incidences of mobility disability and MCI to determine whether the order of their occurrence is differentially associated with risk of death.
resultsThe average age was 75.3 years and 70% were female. While mobility disability occurred more frequently than incident MCI, the subsequent risk of death was higher in participants who developed MCI alone compared to those who developed mobility disability alone (hazard ratio [HR] 1.70, p = 0.018). Of the participants who initially developed mobility disability, about half subsequently developed MCI that doubled their risk of death (HR 2.17, p < 0.001). By contrast, over two-third who developed MCI subsequently developed mobility disability, which did not further increase their risk of death.
conclusionMobility disability occurs more frequently in community-dwelling older adults, but MCI is more strongly associated with mortality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.