ArticlePsychoneuroendocrinology2019
High social strain and physical health: Examining the roles of anxious arousal, body mass index, and inflammation.
Article in Psychoneuroendocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Relationship quality moderates the association between neighborhood disadvantage and cognition among Mexican American older adults.The journals of gerontology. Series B, Psychological sciences and social sciences · 2026Article
- The inflammation-depression link: How social networks buffer or exacerbate risk.Brain, behavior, & immunity - health · 2025Article
- Relationship Between Family Support, C-Reactive Protein and Body Mass Index Among Outpatients with Schizophrenia.Healthcare (Basel, Switzerland) · 2025Article
- The psychosocial anti-inflammatories: Sense of control, purpose in life, and social support in relation to inflammation, functional health and chronic conditions in adulthood.Journal of psychosomatic research · 2024Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Social relationships have powerful effects on physical health. Indeed, high social strain (i.e., frequent negative interactions with friends, family, or one's partner) increases risk of morbidity and mortality. Frequent social strain leads to anxious arousal and an increased body mass index (BMI), both of which may be underlying mechanisms for the association between social strain and health given that persistent anxious arousal promotes damaging biological and behavioral conditions contributing to increased inflammation. When chronic, heightened inflammation results in the deterioration of overall health. The purpose of the current study was to investigate anxious arousal, BMI, and inflammation as underlying mechanisms of the association between social strain and health. A sample of 763 middle aged adults participating in the Midlife in the United States (MIDUS 2) study completed self-report measures of social strain, anxious arousal, and physical health. Blood collection and a physical examination were completed to measure BMI and inflammation. Using 5000 bootstrap samples, results indicated that greater social strain was associated with poorer self-reported health (SRH) due to the serial pathway from high anxious arousal to BMI and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.