Evidence map›Paper›PMID 30986617›Full record

ReviewCurrent opinion in psychology2019

Prospects for reconsolidation-focused treatments of substance use and anxiety-related disorders.

Daniel J Paulus, Sunjeev K Kamboj, Ravi K Das, Michael E Saladin

Abstract readReview
In one paragraph

Review in Current opinion in psychology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Trial
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  11. Review
  12. Neural Computations of Threat.Trends in cognitive sciences · 2021
    Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Daniel J PaulusDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Department of Psychology, University of Houston, Houston, TX, USA.
Sunjeev K KambojClinical Psychopharamacology Unit, Research Department of Clinical, Educational, and Health Psychology, University College London, London, UK.
Ravi K DasClinical Psychopharamacology Unit, Research Department of Clinical, Educational, and Health Psychology, University College London, London, UK.
Michael E SaladinDepartment of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, SC, USA; Department of Health Sciences and Research, College of Health Professions, Medical University of South Carolina Charleston, SC, USA. Electronic address: saladinm@musc.edu.

Funding

TREATING ETHANOL WITHDRAWAL WITH LORAZEPAM/NALTREXONEP50AA010761 · NIAAA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Lisa M McTeague · 1996 to 2026
$46.8M
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI RAYMOND N. DUBOIS · 2009 to 2026
$42.7M
SOUTH CAROLINA CLINICAL & TRANSLATIONAL RESEARCH INSTITUTE (SCTR)UL1RR029882 · NCRR · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2009 to 2011
$10.1M
South Carolina Clinical & Translational Research Institute (SCTR)UL1TR000062 · NCATS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI BRADY, KATHLEEN T. · 2012 to 2014
$9.4M
Enhancing Disrupted Reconsolidation: Impact on Cocaine Craving, Reactivity & UseR01DA035247 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SALADIN, MICHAEL E · 2013 to 2017
$2.4M
Targeting Foundational Memory Processes in Nicotine Addiction: A Translational Clinical Neuroscience Study of a Retrieval-Extinction Intervention to Reduce Craving & Smoking BehaviorR01DA043587 · NIDA · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI SALADIN, MICHAEL E · 2018 to 2021
$2.1M
NCATS NIH HHS UL1 TR000062NCI NIH HHS P30 CA138313NCRR NIH HHS UL1 RR029882NIAAA NIH HHS P50 AA010761NIDA NIH HHS R01 DA035247NIDA NIH HHS R01 DA043587
6 · The paper itself

Abstract

Memories are often conceptualized as permanent entities; however, retrieval of memories via stimulus prompts can return them to an active state, which initiates a period of lability before the memories are reconsolidated into long-term storage. Importantly, during this period, memories can be disrupted/altered. A growing body of work has focused on translating animal and experimental science into reconsolidation-based interventions for clinical disorders maintained by maladaptive memories. Interventions targeting reward-based and fear-based memories undergirding substance use and anxiety-related disorders, respectively, have shown significant potential. There are several promising pharmacological agents and behavioral approaches that have been used to therapeutically target memory reconsolidation. Here, we discuss the current state of science with special emphasis on the clinical utility of these approaches.

Indexed as

Memory ConsolidationAnxiety DisordersFearHumansSubstance-Related Disorders

Identifiers

PMID30986617
PMCPMC6744358

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.