Evidence map›Paper›PMID 30986444›Full record

ArticleMolecular and cellular endocrinology2019

Nuclear estrogen receptor activation by insulin-like growth factor-1 in Neuro-2A neuroblastoma cells requires endogenous estrogen synthesis and is mediated by mutually repressive MAPK and PI3K cascades.

Kevin J Pollard, Jill M Daniel

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Estrogen receptor α: a critical role in successful female cognitive aging.Climacteric : the journal of the International Menopause Society · 2021
    Article
  10. Review
  11. Review
  12. Review
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kevin J PollardTulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA; Neuroscience Program, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA. Electronic address: kpollar@tulane.edu.
Jill M DanielTulane Brain Institute, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA; Neuroscience Program, Tulane University, 200 Flower Hall, New Orleans, LA, 70118, USA; Department of Psychology, Tulane University, 2007 Percival Stern Hall, New Orleans, LA, 70118, USA.
Tulane University · US

Funding

Short-term estradiol use in middle-age: implications for female cognitive agingR01AG041374 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI JILL M DANIEL · 2012 to 2026
$3.0M
Short-term estradiol use in middle-age: implications for female cognitive agingRF1AG041374 · NIA · TULANE UNIVERSITY OF LOUISIANA · PI DANIEL, JILL M · 2018 to 2019
$2.3M
NIA NIH HHS R01 AG041374NIA NIH HHS RF1 AG041374
6 · The paper itself

Abstract

Non-canonical mechanisms of estrogen receptor activation may continue to support women's cognitive health long after cessation of ovarian function. These mechanisms of estrogen receptor activation may include ligand-dependent actions via locally synthesized neuroestrogens and ligand-independent actions via growth factor-dependent activation of intracellular kinase cascades. We tested the hypothesis that ligand-dependent and ligand-independent mechanisms interact to activate nuclear estrogen receptors in the Neuro-2A neuroblastoma cell line in the absence of exogenous estrogens. Transcriptional output of estrogen receptors was measured following treatment with insulin-like growth factor-1 (IGF-1) in the presence of specific inhibitors for mitogen-activated protein kinase (MAPK), phosphoinositde-3 kinase (PI3K), and neuroestrogen synthesis. Results indicate that IGF-1-dependent activation of nuclear estrogen receptors is mediated by MAPK, is opposed PI3K, and requires concomitant endogenous neuroestrogen synthesis. We conclude that both cellular signaling context and endogenous ligand availability are important modulators of ligand-independent nuclear estrogen receptor activation.

Indexed as

MAP Kinase Signaling SystemAnimalsCell Line, TumorCell NucleusEstrogensInsulin-Like Growth Factor IMiceMitogen-Activated Protein KinasesNeuroblastomaPhosphatidylinositol 3-KinasesReceptor, IGF Type 1Receptors, EstrogenTime FactorsEstrogensInsulin-Like Growth Factor IMitogen-Activated Protein KinasesPhosphatidylinositol 3-KinasesReceptor, IGF Type 1Receptors, EstrogenAromataseEstrogen receptorInsulin-like growth factor-1MAPKNeuroestrogensPI3K

Identifiers

PMID30986444
PMCPMC6520186
OpenAlexW2939326919

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.