Evidence map›Paper›PMID 30986420›Full record

ArticleNeuropsychologia2019

White matter integrity in brain structures supporting semantic processing is associated with value-directed remembering in older adults.

Joseph P Hennessee, Nicco Reggente, Michael S Cohen, Jesse Rissman, Alan D Castel, Barbara J Knowlton

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychologia, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. Article
  6. Memory selectivity in older age.Current opinion in psychology · 2024
    Review
  7. Article
  8. Article
  9. Blood Pressure Control and Protection of the Aging Brain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph P HennesseeDepartment of Psychology, University of California, Los Angeles, USA. Electronic address: jhennessee@ucla.edu.
Nicco ReggenteDepartment of Psychology, University of California, Los Angeles, USA; Tiny Blue Dot Foundation, Santa Monica, CA, USA.
Michael S CohenDepartment of Psychology, Northwestern University, USA.
Jesse RissmanDepartment of Psychology, University of California, Los Angeles, USA.
Alan D CastelDepartment of Psychology, University of California, Los Angeles, USA.
Barbara J KnowltonDepartment of Psychology, University of California, Los Angeles, USA.
University of California, Los Angeles · USNorthwestern University · US

Funding

Goals and Motivation to Remember Important Information in Old AgeR01AG044335 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CASTEL, ALAN D · 2013 to 2025
$2.1M
Research Network on Decision Neuroscience and AgingR24AG039350 · NIA · STANFORD UNIVERSITY · PI CARSTENSEN, LAURA L · 2010 to 2014
$896k
Neural Mechanisms Underlying Enhanced Memory for Valuable Items in Healthy AgingF31AG047048 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COHEN, MICHAEL STEWART · 2014 to 2015
$46k
NIA NIH HHS F31 AG047048NIA NIH HHS R01 AG044335NIA NIH HHS R24 AG039350
6 · The paper itself

Abstract

White matter microstructure changes substantially in aging. To better understand how the integrity of white matter structures supports the selective learning of rewarding material, 23 healthy older adults were tested on a value-directed remembering task. This task involved successive free recall word lists where items differed in importance, as denoted by value cues preceding each word. White matter structure was measured using diffusion tensor imaging (DTI). We found that greater structural integrity (as measured by lower mean diffusivity) in left inferior fronto-occipital fasciculus was associated with greater recall for high-value items, but not low-value items. Older adults with greater structural integrity in a tract involved in semantic processing are thus able to more successfully encode high-value items for subsequent recall. However, unlike prior findings in younger adults, older adults' memory for high value-items was not significantly correlated with the structural integrity of the uncinate fasciculus, nor with the strength of anatomical connectedness between the bilateral nucleus accumbens to ventral tegmental area reward pathway. These structural imaging findings add support to recent functional neuroimaging demonstrations that value-related modulation of memory in older adults depends heavily on brain circuits implicated in controlled processing of semantic knowledge.

Indexed as

MemoryRewardAdultAgedAged, 80 and overAge FactorsBrainDiffusion Tensor ImagingFemaleFrontal LobeHumansMaleMiddle AgedNeural PathwaysNucleus AccumbensOccipital LobeAgingDiffusion tensor imagingMemoryRewardSemanticValue

Identifiers

PMID30986420
PMCPMC6571157
OpenAlexW2940164279

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.