ArticleMedical science monitor : international medical journal of experimental and clinical research2019
Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 44 citations in OpenAlex.
- Serum inflammatory cytokines in the progression of depression.Frontiers in immunology · 2026Review
- Retracted: Avicularin Relieves Depressive-Like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Article
- Research progress of quercetin on anti-anxiety and anti-depression.Frontiers in pharmacology · 2025Review
- Avicularin Attenuated Lead-Induced Ferroptosis, Neuroinflammation, and Memory Impairment in Mice.Antioxidants (Basel, Switzerland) · 2024Article
- Lactoferrin deficiency during lactation increases the risk of depressive-like behavior in adult mice.BMC biology · 2023Article
- Systems biology approaches to identify potential targets and inhibitors of the intestinal microbiota to treat depression.Scientific reports · 2023Article
- Flavonols in Action: Targeting Oxidative Stress and Neuroinflammation in Major Depressive Disorder.International journal of molecular sciences · 2023Review
- Avicularin Attenuates Lead-Induced Impairment of Hepatic Glucose Metabolism by Inhibiting the ER Stress-Mediated Inflammatory Pathway.Nutrients · 2022Article
- The Intervention of Prebiotics on Depression via the Gut-Brain Axis.Molecules (Basel, Switzerland) · 2022Review
- Avicularin Attenuates Memory Impairment in Rats with Amyloid Beta-Induced Alzheimer's Disease.Neurotoxicity research · 2022Article
- Antidepressant Potential of Quercetin and itsFrontiers in pharmacology · 2022Review
- Antidepressant-like Effects of Combined Fluoxetine and Zinc Treatment in Mice Exposed to Chronic Restraint Stress Are Related to Modulation of Histone Deacetylase.Molecules (Basel, Switzerland) · 2021Article
- Abnormal expression of miR-135a in patients with depression and its possible involvement in the pathogenesis of the condition.Experimental and therapeutic medicine · 2021Article
- Review
- Antidepressant and Anxiolytic-Like Effects of the Stem Bark Extract ofFrontiers in behavioral neuroscience · 2021Article
- Sex Differences in the Inflammatory Consequences of Stress: Implications for Pharmacotherapy.The Journal of pharmacology and experimental therapeutics · 2020Review
- Avicularin Reduces the Expression of Mediators of Inflammation and Oxidative Stress in Bradykinin-Treated MG-63 Human Osteoblastic Osteosarcoma Cells.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Impacts of Aerobic Exercise on Depression-Like Behaviors in Chronic Unpredictable Mild Stress Mice and Related Factors in the AMPK/PGC-1α Pathway.International journal of environmental research and public health · 2020Article
- Screening and druggability analysis of some plant metabolites against SARS-CoV-2: An integrative computational approach.Informatics in medicine unlocked · 2020Article
Corrections and comments
- Retracted
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND Avicularin (AL, quercetin-3-alpha-l-arabinofuranoside), a glycoside of quercetin, has been reported to display diverse pharmacological properties. The present study aimed to investigate whether AL has an anti-depressant-like effect on a mouse model of depression induced by chronic unpredictable mild stress (CUMS). MATERIAL AND METHODS A mouse model of depression was established and treated with different concentrations of AL (1.25, 2.5 or 5.0 mg/kg/d) and fluoxetine (20 mg/kg/d). Then, behavioral tests - sucrose preference test (SPT), forced swimming test (FST), and the tail suspension test (TST) - were performed. The levels proinflammatory cytokines - interleukin-1ß (IL-1ß), IL-6, and tumor necrosis factor-alpha (TNF-alpha) - in the hippocampi of mice were detected by enzyme-linked immunosorbent assay (ELISA). Apoptosis of hippocampal neuronal cells was determined using flow cytometry. Expression levels of phosphorylated (p)-MEK1/2, p-ERK1/2, p-NF-kappaB (p-p65), inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), Caspase3, and B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax) were measured by Western blot assay or/and quantitative real-time polymerase chain reaction (qRT-PCR), respectively. RESULTS The results showed that AL significantly relieved CUMSinduced depressive-like behaviors. Compared with the model mice, AL treatment significantly increased the sucrose preference of the mice, and the immobility time in the FST and the TST were shortened. We also found that AL decreased CUMS-induced increases in the levels of IL-1ß, IL-6, and TNF-alpha in the hippocampi of mice. AL significantly decreased the apoptosis rate of hippocampal neuronal cells in mice, which was increased by CUMS. Furthermore, activation of the MEK/ERK/NF-kappaB pathway induced by CUMS was inhibited by AL treatment. CONCLUSIONS Our results show the anti-depressant-like effects of AL on CUMS-induced depression in a mouse model.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.