Evidence map›Paper›PMID 30986044›Full record

ReviewBioconjugate chemistry2019

Molecular Tools to Generate Reactive Oxygen Species in Biological Systems.

Ying Xiong, Xiaodong Tian, Hui-Wang Ai

Abstract readReview
In one paragraph

Review in Bioconjugate chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Photosensitizing Antivirals.Molecules (Basel, Switzerland) · 2021
    Review
  14. Chemical approaches for the enhancement of porphyrin skeleton-based photodynamic therapy.Journal of enzyme inhibition and medicinal chemistry · 2020
    Review
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Ying XiongCenter for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, Department of Chemistry, and the UVA Cancer Center , University of Virginia , 1340 Jefferson Park Avenue , Charlottesville , Virginia 22908 , United States.
Xiaodong TianCenter for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, Department of Chemistry, and the UVA Cancer Center , University of Virginia , 1340 Jefferson Park Avenue , Charlottesville , Virginia 22908 , United States.
Hui-Wang AiCenter for Membrane and Cell Physiology, Department of Molecular Physiology and Biological Physics, Department of Chemistry, and the UVA Cancer Center , University of Virginia , 1340 Jefferson Park Avenue , Charlottesville , Virginia 22908 , United States.ORCID 0000-0002-5664-3270

Funding

Red and Far-Red Fluorescent Biosensors for Compartmentalized Redox SignalingR01GM129291 · NIGMS · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2018 to 2021
$2.1M
A Fluorescent Toolkit for Imaging Reactive Oxygen Species (ROS)R01GM118675 · NIGMS · UNIVERSITY OF VIRGINIA · PI AI, HUIWANG · 2016 to 2019
$1.4M
NIGMS NIH HHS R01 GM118675NIGMS NIH HHS R01 GM129291
6 · The paper itself

Abstract

Reactive oxygen species (ROS) not only are byproducts of aerobic respiration, but also play vital roles in metabolism regulation and signal transductions. It is important to understand the functions of ROS in biological systems. In addition, scientists have made use of ROS to kill bacteria and tumors through a process known as photodynamic therapy (PDT). This paper provides a concise review of current molecular tools that can generate ROS in biological systems via either nongenetic or genetically encoded way. Challenges and perspectives are further discussed with the hope of broadening the applications of ROS generators in research and clinical settings.

Indexed as

HumansNanotechnologyPeroxidasePhotochemotherapyPhotosensitizing AgentsReactive Oxygen SpeciesSignal TransductionXanthine OxidasePeroxidasePhotosensitizing AgentsReactive Oxygen SpeciesXanthine Oxidase

Identifiers

PMID30986044
PMCPMC6528174

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.