ArticleCancer2019
Ambulatory status after surgical and nonsurgical treatment for spinal metastasis.
Article in Cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Reporting of Observational Studies Explicitly Aiming to Emulate Randomized Trials: A Systematic Review.JAMA network open · 2023Pooled it
- Evaluating ambulatory function as an outcome following treatment for spinal metastases: a systematic review.The spine journal : official journal of the North American Spine Society · 2021Pooled it
- Target trial emulation studies in oncology: a comprehensive analysis.The oncologist · 2026Article
- A three-dimensional finite element-based biomechanical properties analysis of the 10th thoracic vertebra invaded by bone metastases for clinical procedure optimization.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Design and Implementation of Observational Studies Emulating a Target Trial.JAMA network open · 2026Article
- Regional variability and economic impact on surgical practices for metastatic spinal disease in Europe - a survey on spine surgeons.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Trends in the surgical treatment for metastatic spinal tumor in Japanese administrative data between 2012 and 2020.International journal of clinical oncology · 2024Article
- Development and internal validation of machine-learning models for predicting survival in patients who underwent surgery for spinal metastases.Asian spine journal · 2024Article
- Article
- Clinical Characteristics, Surgical Outcomes, and Risk Factors for Emergency Surgery in Patients With Spinal Metastases: A Prospective Cohort Study.Neurospine · 2024Article
- Development of Machine-Learning Models to Predict Ambulation Outcomes Following Spinal Metastasis Surgery.Asian spine journal · 2023Article
- Determining patients with spinal metastases suitable for surgical intervention: A cost-effective analysis.Cancer medicine · 2023Article
- Clinical Characteristics and Surgical Outcomes of Metastatic Spine Tumors in the Very Elderly: A Prospective Cohort Study in a Super-Aged Society.Journal of clinical medicine · 2023Article
- Telemedicine visits generate accurate surgical plans across orthopaedic subspecialties.Archives of orthopaedic and trauma surgery · 2022Article
- Cost-Utility Analysis Compared Between Radiotherapy Alone and Combined Surgery and Radiotherapy for Symptomatic Spinal Metastases in Thailand.Neurospine · 2022Article
- Randomized controlled trials and high-intensity spine surgery.The spine journal : official journal of the North American Spine Society · 2020Article
- Patient experiences of decision-making in the treatment of spinal metastases: a qualitative study.The spine journal : official journal of the North American Spine Society · 2020Article
- Outcomes of surgical treatments of spinal metastases: a prospective study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2020Article
- Non-operative management of spinal metastases: A prognostic model for failure.Clinical neurology and neurosurgery · 2020Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundDecisions for operative or nonoperative management remain challenging for patients with spinal metastases, especially when life expectancy and quality of life are not easily predicted. This study evaluated the effects of operative and nonoperative management on maintenance of ambulatory function and survival for patients treated for spinal metastases.
methodsPropensity matching was used to yield an analytic sample in which operatively and nonoperatively treated patients were similar with respect to key baseline covariates. The study included patients treated for spinal metastases between 2005 and 2017 who were 40 to 80 years old, were independent ambulators at presentation, and had fewer than 5 medical comorbidities. It evaluated the influence of operative care and nonoperative care on ambulatory function 6 months after presentation as the primary outcome. Survival at 6 months and survival at 1 year were secondary outcomes.
resultsNine hundred twenty-nine individuals eligible for inclusion were identified, with 402 (201 operative patients and 201 nonoperative patients) retained after propensity score matching. Patients treated operatively had a lower likelihood than those treated nonoperatively of being nonambulatory 6 months after presentation (3% vs 16%; relative risk [RR], 0.16; 95% confidence interval [CI], 0.06-0.46) as well as a reduced risk of 6-month mortality (20% vs 29%; RR, 0.69; 95% CI, 0.49-0.98).
conclusionsThese results indicate that in a group of patients with similar demographic and clinical characteristics, those treated operatively were less likely to lose ambulatory function 6 months after presentation than those managed nonoperatively. For patients with spinal metastases, our data can be incorporated into discussions about the treatments that align best with patients' preferences regarding surgical risk, mortality, and ambulatory status.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.