ArticleTransplantation2019
Sarcopenia Predicts Post-transplant Mortality in Acutely Ill Men Undergoing Urgent Evaluation and Liver Transplantation.
Article in Transplantation, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06909942 (Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Association of Sarcopenia With Rocuronium Use in Liver Transplant Recipients
Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Imaging-based assessment of sarcopenia in liver transplant candidates: A systematic review.World journal of gastroenterology · 2025Pooled it
- Prevalence and clinical impact of sarcopenia in liver transplant recipients: A meta-analysis.World journal of gastroenterology · 2024Pooled it
- Malnutrition, Frailty, and Sarcopenia in Patients With Cirrhosis: 2021 Practice Guidance by the American Association for the Study of Liver Diseases.Hepatology (Baltimore, Md.) · 2021Guideline
- Elective Transjugular Intrahepatic Portosystemic Shunt Creation in Cirrhosis Improves Body Composition and Function: Pilot Randomized Trial.Cardiovascular and interventional radiology · 2026Trial
- Low muscle mass predicts liver-related outcomes in cirrhosis, independent of portal hypertension: A retrospective cohort study.Canadian liver journal · 2026Article
- Pre-transplant physical performance, muscle quality, and body composition as predictors of post-liver transplant outcomes: a retrospective cohort study.European journal of medical research · 2026Article
- Association Between Survival After Living Donor Liver Transplantation and Recipient Systemic Inflammation and Body Composition.Journal of clinical medicine · 2025Article
- MCAUnet: a deep learning framework for automated quantification of body composition in liver cirrhosis patients.BMC medical imaging · 2025Article
- Bone mineral density as a prognostic marker in patients with biliary tract cancer undergoing surgery.BJC reports · 2024Article
- Comparing Functional Frailty and Radiographic Sarcopenia as Predictors of Outcomes After Liver Transplant.Clinical transplantation · 2024Article
- Association of Muscle Mass Loss with Diabetes Development in Liver Transplantation Recipients.Diabetes & metabolism journal · 2024Article
- Impact of sarcopenia on the survival of patients undergoing liver transplantation for decompensated liver cirrhosis.Journal of cachexia, sarcopenia and muscle · 2023Article
- Body composition and short-term mortality in patients critically ill with acute-on-chronic liver failure.JHEP reports : innovation in hepatology · 2023Article
- From Listing to Recovery: A Review of Nutritional Status Assessment and Management in Liver Transplant Patients.Nutrients · 2023Review
- Association between Abdominal CT Measurements of Body Composition before Deceased Donor Liver Transplant with Posttransplant Outcomes.Radiology · 2023Article
- Sarcopenic visceral obesity is associated with increased post-liver transplant mortality in acutely ill patients with cirrhosis.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022Article
- Visceral Adipose Tissue Inflammation and Radiographic Visceral-to-Subcutaneous Adipose Tissue Ratio in Patients with Cirrhosis.Digestive diseases and sciences · 2022Article
- Implications of pre-transplant sarcopenia and frailty in patients with non-alcoholic steatohepatitis and alcoholic liver disease.Translational gastroenterology and hepatology · 2022Review
- Sarcopenia Predicts Cancer Mortality in Male but Not in Female Patients Undergoing Surgery for Cholangiocellular Carcinoma.Cancers · 2021Article
- The liver transplant risk score prognosticates the outcomes of liver transplant recipients at listing.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2021Article
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10 authors.
Funding
Abstract
backgroundWe examined the association between sarcopenia and post-transplant mortality in acutely ill inpatients with cirrhosis who underwent urgent liver transplantation.
methodsIncluded were inpatients at 4 centers who were urgently listed as nonstatus 1 and transplanted from 2005 to 2017 with an abdominal computed tomography scan <90 days before transplantation. Skeletal muscle index (SMI) = total skeletal muscle cross-sectional area at the L3 vertebral level, normalized to height. Cox regression associated SMI with post-transplant mortality. Optimal search identified SMI cutoffs to detect survival.
resultsOf 126 inpatients, 63% were male patients, model for end-stage liver disease (MELDNa) was 32, and follow up was 5.1 years. Among men, 23% died. Median SMI was lower in men who died versus survived (45 versus 51 cm/m). SMI was associated with post-transplant mortality (hazard ratio [HR] = 0.96 per cm/m, 95% CI 0.92-0.99). Patients with SMI ≤ 48 cm/m versus >48 cm/m experienced higher rates of death at 1 year (86% versus 95%) and 3 years (73% versus 95%) (Log-rank P = 0.01). In MELD-adjusted analysis, sarcopenia was strongly associated with post-transplant mortality (HR = 4.39, 95% CI 1.49-12.97). Among women, 35% died. Median SMI was similar in women who died versus survived (45 versus 44 cm/m). SMI was not associated with post-transplant mortality (HR = 1.02, 95% CI 0.96-1.09). Optimal search did not identify any SMI cutoff that predicted post-transplant mortality.
conclusionsAmong patients who underwent urgent inpatient evaluation and liver transplantation, we identified an SMI cutoff value of 48 cm/m to predict post-transplant mortality in men. Our data support the use of SMI as a tool to capture the impact of muscle depletion on post-transplant mortality in acutely ill men with cirrhosis undergoing urgent liver transplantation.
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