Evidence map›Paper›PMID 30985534›Full record

Trial reportEpidemiology (Cambridge, Mass.)2019

Metabolic Syndrome and the Effectiveness of Low-dose Aspirin on Reproductive Outcomes.

Carrie J Nobles, Pauline Mendola, Sunni L Mumford, Keewan Kim, Lindsey Sjaarda, Micah Hill, Robert M Silver, Ashley I Naimi, Neil J Perkins, Enrique F Schisterman

Open access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Epidemiology (Cambridge, Mass.), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Elevated lipoprotein(a) and adverse pregnancy outcomes.Annals of medicine and surgery (2012) · 2026
    Review
  3. Article
  4. Maternal Lipids in Pregnancy and Later Life Dyslipidemia: The POUCHmoms Longitudinal Cohort Study.BJOG : an international journal of obstetrics and gynaecology · 2025
    Article
  5. Article
  6. Article
  7. Effects of non-surgical treatment of chronic periodontitis on insulin resistance and glucose tolerance in subjects without diabetes (PARODIA 2 study).Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Carrie J NoblesFrom the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Pauline MendolaFrom the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Sunni L MumfordFrom the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Keewan KimFrom the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Lindsey SjaardaFrom the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Micah HillDepartment of Obstetrics and Gynecology, Walter Reed National Military Medical Center, Bethesda, MD.
Robert M SilverObstetrics and Gynecology, School of Medicine, University of Utah, Salt Lake City, UT.
Ashley I NaimiDepartment of Epidemiology, School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Neil J PerkinsFrom the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Enrique F SchistermanFrom the Epidemiology Branch, Division of Intramural Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD.
Eunice Kennedy Shriver National Institute of Child Health and Human Development · USUniversity of Pittsburgh · USUniversity of Utah · USWalter Reed National Military Medical Center · US

Funding

EAGeR Trial - The Effects of Aspirin in Gestation and Reproduction TrialZIAHD008795 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PERKINS, NEIL · 2009 to 2025
$9.6M
Estimating the Effect of Low-Dose Aspirin on Fetal Loss in a Trial with Non-ComplianceR01HD093602 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NAIMI, ASHLEY ISAAC · 2018 to 2021
$1.2M
Intramural NIH HHS ZIA HD008795NICHD NIH HHS R01 HD093602
6 · The paper itself

Abstract

backgroundMetabolic syndrome is associated with increases in both inflammation and aspirin resistance, but effectiveness of aspirin in improving reproductive health among women with metabolic syndrome is unknown. We evaluated the effectiveness of low-dose aspirin in improving reproductive outcomes across metabolic syndrome score.

methodsThe EAGeR trial randomly assigned 1228 women with a history of pregnancy loss to receive 81 mg aspirin or placebo for up to six menstrual cycles of attempting pregnancy and, if they became pregnant, throughout pregnancy. We assessed components of metabolic syndrome at enrollment, including: waist circumference ≥88 cm, triglycerides ≥150 mg/dl, high-density lipoprotein ≤50 mg/dl, blood pressure ≥130 mmHg systolic or ≥85 mmHg diastolic, and glucose ≥100 mg/dl. We summed components to calculate metabolic syndrome score.

resultsA total of 229 participants (20%) met full criteria for metabolic syndrome, 207 (18%) had two components, 366 (31%) one component, and 372 (32%) no components. Among those without any component of metabolic syndrome, aspirin was associated with 10.7 [95% confidence interval (CI) = 1.2, 20.2] more pregnancies and 13.7 (95% CI = 3.3, 24.0) more live births per 100 couples. Effects were attenuated as metabolic syndrome score increased and we observed no clear effect of aspirin on pregnancy or live birth among women with metabolic syndrome.

conclusionsLow-dose aspirin is most effective in increasing pregnancy and live birth among women with no or few components of metabolic syndrome. Reduced effectiveness among women with metabolic syndrome may be due to differences in effective dose or aspirin resistance.

Indexed as

Abortion, SpontaneousAdultAspirinDose-Response Relationship, DrugDouble-Blind MethodDrug Administration ScheduleFemaleFollow-Up StudiesHumansInfertility, FemaleLive BirthMetabolic SyndromePregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesAspirin

Identifiers

PMID30985534
PMCPMC6548668
OpenAlexW2937586093

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.