Evidence map›Paper›PMID 30985475›Full record

ReviewExercise and sport sciences reviews2019

Exercise-Induced Mitophagy in Skeletal Muscle and Heart.

Yuntian Guan, Joshua C Drake, Zhen Yan

Abstract readReview
In one paragraph

Review in Exercise and sport sciences reviews, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed.

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  13. Mitochondrial proteostasis regulated by CRL5Communications biology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yuntian GuanDepartment of Pharmacology.
Joshua C DrakeCenter for Skeletal Muscle Research at the Robert M. Berne Cardiovascular Research Center.
Zhen YanDepartment of Pharmacology.

Funding

p38 MAPK a regulator of muscle contraction and functionR01AR050429 · NIAMS · VIRGINIA POLYTECHNIC INST AND ST UNIV · PI YAN, ZHEN · 2005 to 2022
$5.3M
Role of skeletal muscle mitophagy in healthy agingK99AG057825 · NIA · UNIVERSITY OF VIRGINIA · PI DRAKE, JOSH C · 2018 to 2019
$207k
NIAMS NIH HHS R01 AR050429NIA NIH HHS K99 AG057825
6 · The paper itself

Abstract

Regular exercise enhances mitochondrial function by promoting healthy mitochondrial remodeling, but the underlying mechanisms are not thoroughly understood. An emerging hypothesis suggests that, in addition to anabolic events such as mitochondria biogenesis, the selective degradation of dysfunctional mitochondria (i.e., mitophagy) also is a key component of exercise-mediated adaptations in striated muscle, which eventually leads to better mitochondrial functions.

Indexed as

MitophagyAdaptation, PhysiologicalAMP-Activated Protein Kinase KinasesExerciseHumansMitochondria, HeartMitochondria, MuscleMuscle, SkeletalPhysical Conditioning, HumanProtein KinasesAMP-Activated Protein Kinase KinasesProtein Kinases

Identifiers

PMID30985475
PMCPMC6579614

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.