Evidence map›Paper›PMID 30985404›Full record

ArticlePsychosomatic medicine2019

Hopelessness and Other Depressive Symptoms in Adults 70 Years and Older as Predictors of All-Cause Mortality Within 3 Months After Acute Hospitalization: The Hospital-ADL Study.

Lucienne A Reichardt, Floor E Nederveen, Rosanne van Seben, Jesse J Aarden, Marike van der Schaaf, Raoul H H Engelbert, Martin van der Esch, Marieke J Henstra, Jos W R Twisk, Jos A Bosch and 2 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Psychosomatic medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Association of Depression Dimensions With Cognitive Functioning in Community-Dwelling Oldest-Old Adults: The LifeAfter90 Study.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Lucienne A ReichardtFrom the Department of Internal Medicine (Reichardt, Nederveen, van Seben, Henstra, Buurman), Section of Geriatric Medicine, Amsterdam Public Health Research Institute, Amsterdam UMC, University of Amsterdam; Department of Rehabilitation (Aarden, van der Schaaf, Engelbert), Amsterdam Movement Sciences, Amsterdam UMC, University of Amsterdam; ACHIEVE - Center of Applied Research (Aarden, Engelbert, van der Esch, Buurman), Faculty of Health, Amsterdam University of Applied Sciences; Reade (Esch), Center for Rehabilitation and Rheumatology/Amsterdam Rehabilitation Research Center; Department of Epidemiology and Biostatistics (Twisk), Amsterdam UMC, Vrije Universiteit Amsterdam; Department of Clinical Psychology (Bosch), University of Amsterdam; and Department of Psychology (Bosch), Section of Psychology, Amsterdam UMC, University of Amsterdam, the Netherlands (Bosch).
Floor E Nederveen
Rosanne van Seben
Jesse J Aarden
Marike van der Schaaf
Raoul H H Engelbert
Martin van der Esch
Marieke J Henstra
Jos W R Twisk
Jos A Bosch
Bianca M Buurman
Hospital-ADL Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveDepression among older adults predicts mortality after acute hospitalization. Depression is highly heterogeneous in its presentation of symptoms, whereas individual symptoms may differ in predictive value. This study aimed to investigate the prevalence of individual cognitive-affective depressive symptoms during acute hospitalization and investigate the predictive value of both overall and individual cognitive-affective depressive symptoms for mortality between admission up to 3-month postdischarge among older patients.

methodsA prospective multicenter cohort study enrolled 401 acutely hospitalized patients 70 years and older (Hospitalization-Associated Disability and impact on daily Life Study). The predictive value of depressive symptoms, assessed using the Geriatric Depression Scale 15, during acute hospitalization on mortality was analyzed with multiple logistic regression.

resultsThe analytic sample included 398 patients (M (SD) = 79.6 (6.6) years; 51% men). Results showed that 9.3% of participants died within 3 months, with symptoms of apathy being most frequently reported. The depression total score during hospitalization was associated with increased mortality risk (admission: odds ratio [OR] = 1.2, 95% confidence interval [CI] = 1.2-1.3; discharge: OR = 1.2, 95% CI = 1.2-1.4). Stepwise multiple logistic regression analyses yielded the finding that feelings of hopelessness during acute hospitalization were a strong unique predictor of mortality (admission: OR = 3.6, 95% CI = 1.8-7.4; discharge: OR = 5.7, 95% CI = 2.5-13.1). These associations were robust to adjustment for demographic factors, somatic symptoms, and medical comorbidities.

conclusionsSymptoms of apathy were most frequently reported in response to acute hospitalization. However, feelings of hopelessness about their situation were the strongest cognitive-affective predictor of mortality. These results imply that this item is important in identifying patients who are in the last phase of their lives and for whom palliative care may be important.

Indexed as

Cause of DeathGeriatric AssessmentPatient DischargeAcute DiseaseAgedAged, 80 and overAgingApathyDepressionFemaleHopeHumansMalePredictive Value of TestsProspective StudiesPsychiatric Status Rating Scales

Identifiers

PMID30985404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.