Evidence map›Paper›PMID 30985304›Full record

ArticleASAIO journal (American Society for Artificial Internal Organs : 1992)2020

Hemodynamic Effects of Concomitant Mitral Valve Surgery and Left Ventricular Assist Device Implantation.

Teruhiko Imamura, Jerry Nnanabu, Daniel Rodgers, Jayant Raikehlkar, Sara Kalantar, Bryan Smith, Ann Nguyen, Ben Chung, Nikhil Narang, Takeyoshi Ota and 6 more

Abstract read
In one paragraph

Article in ASAIO journal (American Society for Artificial Internal Organs : 1992), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Teruhiko ImamuraFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Jerry NnanabuFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Daniel RodgersFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Jayant RaikehlkarFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Sara KalantarFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Bryan SmithFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Ann NguyenFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Ben ChungFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Nikhil NarangFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Takeyoshi OtaDepartment of Surgery, University of Chicago Medical Center, Chicago, Illinois.
Tae SongDepartment of Surgery, University of Chicago Medical Center, Chicago, Illinois.
Daniel BurkhoffColumbia University Medical Center, and Cardiovascular Research Foundation, New York, New York.
Valluvan JeevanandamDepartment of Surgery, University of Chicago Medical Center, Chicago, Illinois.
Gene KimFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Gabriel SayerFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.
Nir UrielFrom the Department of Medicine; University of Chicago Medical Center, Chicago, Illinois.

Funding

MULTIDISCIPLINARY CARDIAC SCIENCEST32HL007381 · NHLBI · UNIVERSITY OF CHICAGO · PI JEANNE M DECARA, Yoav Gilad · 1985 to 2026
$12.5M
NHLBI NIH HHS T32 HL007381
6 · The paper itself

Abstract

There are conflicting data regarding whether concomitant mitral valve surgery (MVS) at left ventricular assist device (LVAD) implantation is beneficial. This study aimed to assess the hemodynamic effects of concomitant MVS. Of all 73 enrolled patients, 44 patients had undergone concomitant MVS and 29 patients had not. Before LVAD implantation, MVS group had higher pulmonary capillary wedge pressure (p = 0.04). After LVAD implantation, MVS group had higher mean pulmonary artery pressure and cardiac output (CO). During the hemodynamic ramp study, MVS group had steeper CO slopes (0.18 [0.13 0.28] vs. 0.15 [0.08, 0.20] L/min/step; p = 0.04) at incremental LVAD speed and achieved a higher CO at the optimized set speed (5.5 [4.7, 6.9] vs. 4.9 [4.0, 5.7] L/min; p = 0.03). One-year freedom from death or heart failure readmission was statistically comparable between the two groups (61% vs. 80%, p = 0.20). Thus far, after LVAD implantation and concomitant MVS, patients had increased pulmonary hypertension, despite having higher CO and a better response of CO at incremental LVAD speed. The implication of hemodynamic features after concomitant MVS on clinical outcomes warrants further investigation.

Indexed as

Heart-Assist DevicesAgedCardiac OutputFemaleHeart FailureHemodynamicsHumansMaleMiddle AgedMitral Valve

Identifiers

PMID30985304
PMCPMC7081836

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.