ArticleeLife2019
Anterior insular cortex plays a critical role in interoceptive attention.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 105 papers, 3 of them syntheses that pooled it.
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Who cites it
105 citing papers in PubMed, 3 syntheses or guidelines pooled it.
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- Neural Substrates of Brand Love: An Activation Likelihood Estimation Meta-Analysis of Functional Neuroimaging Studies.Frontiers in neuroscience · 2020Pooled it
- Interoceptive Exposure Impacts Food-Cue Extinction in Adolescents With Low-Weight Eating Disorders: A Functional Magnetic Resonance Imaging Study.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Trial
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- An atlas of primate insular cortex reveals a signal-processing strategy in von Economo neurons.Nature cell biology · 2026Article
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- CGRP reception potentiates anxiety in an influenza A derived immune engram.bioRxiv : the preprint server for biology · 2026Article
- Disrupted neural response timing and duration during hand movement preparation in schizophrenia spectrum disorder: An fMRI study.Scientific reports · 2026Article
- Patient-Reported Feedback Suggests an Alternative Sweet Spot for Deep Brain Stimulation Programming in Essential Tremor.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Modulating cue-induced craving in alcohol dependence syndrome: A functional magnetic resonance imaging blood oxygen level-dependent activation study of adjunctive cathodal high-definition transcranial direct current stimulation over the insula.Indian journal of psychiatry · 2026Article
- Respiratory phase alignment across memory encoding and retrieval improves task efficiency.Scientific reports · 2026Article
- Respiration as a dynamic modulator of sensory sampling.Nature communications · 2026Article
- Brain network functional connectivity changes induced by music-induced analgesia in fibromyalgia patients.Scientific reports · 2026Article
- Functional inputs to the subgenual cingulate cortex differentiate levels of depressive symptom severity in neurotypical young adults: granger causality and clustering analyses.The international journal of neuropsychopharmacology · 2026Article
45 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
Accumulating evidence indicates that the anterior insular cortex (AIC) mediates interoceptive attention which refers to attention towards physiological signals arising from the body. However, the necessity of the AIC in this process has not been demonstrated. Using a novel task that directs attention toward breathing rhythm, we assessed the involvement of the AIC in interoceptive attention in healthy participants using functional magnetic resonance imaging and examined the necessity of the AIC in interoceptive attention in patients with AIC lesions. Results showed that interoceptive attention was associated with increased AIC activation, as well as enhanced coupling between the AIC and somatosensory areas along with reduced coupling between the AIC and visual sensory areas. In addition, AIC activation was predictive of individual differences in interoceptive accuracy. Importantly, AIC lesion patients showed disrupted interoceptive discrimination accuracy and sensitivity. These results provide compelling evidence that the AIC plays a critical role in interoceptive attention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.