ArticleeLife2019
A cross-modality enhancement of defensive flight via parvalbumin neurons in zona incerta.
Article in eLife, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Dopamine dynamics as a regulatory mechanism for shifting between defensive and reward-seeking behaviors.Communications biology · 2026Article
- Multimodal analysis reveals cellular diversity and divergent circuits of the zona incerta.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Somatosensory control of thalamic relay neurons is regulated by two distinct layer 6 feedback systems.iScience · 2026Article
- Direction-selective laterodorsal thalamic nucleus encodes optic flow and turning in spatial navigation.Neuron · 2025Article
- Dual and plasticity-dependent regulation of cerebello-zona incerta circuits on anxiety-like behaviors.Nature communications · 2025Article
- Transcriptomic and spatial GABAergic neuron subtypes in zona incerta mediate distinct innate behaviors.Nature communications · 2025Article
- The zona incerta negatively regulates the red nucleus during movement cued by sound signals.PLoS biology · 2025Article
- Cholecystokinin neurons in the spinal trigeminal nucleus interpolaris regulate mechanically evoked predatory hunting in male mice.Nature communications · 2025Article
- Reviving-like prosocial behavior in response to unconscious or dead conspecifics in rodents.Science (New York, N.Y.) · 2025Article
- Aberrant outputs of cerebellar nuclei and targeted rescue of social deficits in an autism mouse model.Protein & cell · 2024Article
- A distributed auditory network mediated by pontine central gray underlies ultra-fast awakening in response to alerting sounds.Current biology : CB · 2024Article
- Dopaminergic Neurons in Zona Incerta Drives Appetitive Self-Grooming.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cross-modal enhancement of defensive behavior via parabigemino-collicular projections.Current biology : CB · 2024Article
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- Inhibitory medial zona incerta pathway drives exploratory behavior by inhibiting glutamatergic cuneiform neurons.Nature communications · 2024Article
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- Zona incerta dopamine neurons encode motivational vigor in food seeking.Science advances · 2023Article
- Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions.Neuron · 2023Article
- Negative Emotions Recruit the Parabrachial Nucleus Efferent to the VTA to Disengage Instrumental Food Seeking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Pathway-specific inputs to the superior colliculus support flexible responses to visual threat.Science advances · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The ability to adjust defensive behavior is critical for animal survival in dynamic environments. However, neural circuits underlying the modulation of innate defensive behavior remain not well-understood. In particular, environmental threats are commonly associated with cues of multiple sensory modalities. It remains to be investigated how these modalities interact to shape defensive behavior. In this study, we report that auditory-induced defensive flight behavior can be facilitated by somatosensory input in mice. This cross-modality modulation of defensive behavior is mediated by the projection from the primary somatosensory cortex (SSp) to the ventral sector of zona incerta (ZIv). Parvalbumin (PV)-positive neurons in ZIv, receiving direct input from SSp, mediate the enhancement of the flight behavior via their projections to the medial posterior complex of thalamus (POm). Thus, defensive flight can be enhanced in a somatosensory context-dependent manner via recruiting PV neurons in ZIv, which may be important for increasing survival of prey animals.
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