ArticleJournal of refractive surgery (Thorofare, N.J. : 1995)2019
Biomechanical Impact of Localized Corneal Cross-linking Beyond the Irradiated Treatment Area.
Article in Journal of refractive surgery (Thorofare, N.J. : 1995), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04598932 (Corneal Biomechanical Analysis Using Brillouin Microscopy), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Corneal Biomechanical Analysis Using Brillouin Microscopy
Who cites it
12 citing papers in PubMed.
- Outcomes of localized corneal collagen crosslinking with a conventional device in progressive keratoconus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Quantitative assessment of corneal biomechanical changes in vivo after photorefractive intrastromal corneal cross-linking using optical coherence elastography.Quantitative imaging in medicine and surgery · 2024Article
- Review
- Use of Nanoindentation in Determination of Regional Biomechanical Properties of Rabbit Cornea After UVA Cross-Linking.Investigative ophthalmology & visual science · 2023Article
- Advances in Imaging Technology of Anterior Segment of the Eye.Journal of ophthalmology · 2021Review
- A review of imaging modalities for detecting early keratoconus.Eye (London, England) · 2021Review
- Changes in Collagen Structure and Permeability of Rat and Human Sclera After Crosslinking.Translational vision science & technology · 2020Article
- Detecting Mechanical Anisotropy of the Cornea Using Brillouin Microscopy.Translational vision science & technology · 2020Article
- Multifunctional synthetic Bowman's membrane-stromal biomimetic for corneal reconstruction.Biomaterials · 2020Article
- Corneal Collagen Ordering After In Vivo Rose Bengal and Riboflavin Cross-Linking.Investigative ophthalmology & visual science · 2020Article
- Optical coherence elastography by ambient pressure modulation for high-resolution strain mapping applied to patterned cross-linking.Journal of the Royal Society, Interface · 2020Article
- Delayed-Onset Transient Light Sensitivity Syndrome after Corneal Collagen Cross-Linking: A Case Series.Medical hypothesis, discovery & innovation ophthalmology journal · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purposeTo investigate the stiffening effect of localized corneal cross-linking (L-CXL) within and beyond the irradiated region in three dimensions.
methodsTen porcine eyes were debrided of epithelium and incrementally soaked with 0.1% riboflavin solution. Using a customized, sharp-edged mask, half of the cornea was blocked while the other half was exposed to blue light (447 nm). The three-dimensional biomechanical properties of each cornea were then measured via Brillouin microscopy. An imaging system was used to quantify the optimal transition zone between cross-linked and non-cross-linked sections of the cornea when considering light propagation and scattering.
resultsA broad transition zone of 610 µm in width was observed between the fully cross-linked and non-cross-linked sections, indicating the stiffening response extended beyond the irradiated region. Light propagation and the scattering induced by the riboflavin-soaked cornea accounted for a maximum of 25 and 159 ± 3.2 µm, respectively.
conclusionsThe stiffening effect of L-CXL extends beyond that of the irradiated area. When considering L-CXL protocols clinically, it will be important to account for increased stiffening in surrounding regions. [J Refract Surg. 2019;35(4):253-260.].
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