ArticleJNCI cancer spectrum2019
Trends in International Incidence of Pediatric Cancers in Children Under 5 Years of Age: 1988-2012.
Article in JNCI cancer spectrum, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07278674 (Clinical Study of Eflornithine After Immunotherapy for High-risk Neuroblastoma（CSHEIN）), which is not on this map. Cited by 56 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Study of Eflornithine After Immunotherapy for High-risk Neuroblastoma（CSHEIN）
Who cites it
56 citing papers in PubMed, 4 syntheses or guidelines pooled it, 125 citations in OpenAlex.
- Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2025Pooled it
- Cumulative temporal association between assisted reproductive technology and childhood cancer: a systematic review and meta-analysis of observational studies.Frontiers in oncology · 2025Pooled it
- Virtual reality in chemotherapy support for the treatment of physical functions, fear, and quality of life in pediatric cancer patients: A systematic review and meta-analysis.Frontiers in public health · 2023Pooled it
- Maternal Body Mass Index, Diabetes, and Gestational Weight Gain and Risk for Pediatric Cancer in Offspring: A Systematic Review and Meta-Analysis.JNCI cancer spectrum · 2022Pooled it
- Improved Detection of Bone Metastases in Children and Young Adults with Ferumoxytol-enhanced MRI.Radiology. Imaging cancer · 2023Trial
- Prognostic prediction of hepatoblastoma in children: development and validation of machine learning models-an SEER-based study.Updates in surgery · 2026Article
- Trends in Childhood and Adolescent Cancer Incidence Rates in the United States between 2001 and 2022.Cancer discovery · 2026Article
- Upregulation of the lncRNACells · 2026Article
- Integrated machine learning and multi-dataset analysis identify SDS as a diagnostic and immune-related hub gene in hepatoblastoma.Frontiers in oncology · 2026Article
- The Mutational Epidemiology of Childhood Cancer.Clinical chemistry · 2025Review
- Review
- Enrollment in Children's Oncology Group's clinical trials: population-based linkage with the National Childhood Cancer Registry.Journal of the National Cancer Institute · 2025Article
- From preneoplastic lesion to heterogenous tumor: recent insights into hepatoblastoma biology and therapeutic opportunities.Molecular cancer · 2025Review
- Therapeutic targeting de novo purine biosynthesis driven by β-catenin-dependent PPAT upregulation in hepatoblastoma.Cell death & disease · 2025Article
- The relative contributions of genetic and non-genetic factors to the risk of neuroblastoma.Pediatric investigation · 2025Review
- Integrated molecular characterization reveals the pathogenesis and therapeutic strategies of pulmonary blastoma.Journal of the National Cancer Center · 2025Article
- Simpson-Golabi-Behmel syndrome type 1 in a neonate with central hepatoblastoma.BMJ case reports · 2025Article
- "Update on pediatric primary liver tumors".Virchows Archiv : an international journal of pathology · 2025Review
- Outcomes of liver transplantation of hepatoblastoma: single-center data in mainland China.Frontiers in pediatrics · 2025Article
- Post-traumatic stress disorder and symptoms in paediatric cancer survivors and their family nucleus: systematic review, meta-analysis and meta-regression.BJPsych open · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundPediatric cancer incidence has been steadily increasing over the last several decades with the largest increases reported in infants. Few evaluations have looked at international pediatric cancer incidence trends in the youngest children. The aim of this analysis was to evaluate trends in cancer incidence in children under 5 years of age, overall and by type, using data from
methodsRates of cancers in children ages 0-4 years were extracted from registries available in
resultsOverall, in children under 5 years, increasing incidence was seen in multiple regions for acute lymphoblastic leukemia, acute myeloid leukemia, ependymal tumors, neuroblastoma, and hepatoblastoma. Hepatoblastoma had the largest AAPC in 11 out of 15 regions and showed an increase in all regions except southern Asia. Astrocytic tumors were the only cancer that decreased over the time period.
conclusionsWe evaluated 25 years of cancer incidence in children ages 0-4 years and observed increases in incidence for hepatoblastoma, leukemia, neuroblastoma, and ependymal tumors. Further etiologic evaluation will be required to explain these increases in incidence.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.