ArticleFrontiers in chemistry2019
Self-Assembled Biocompatible Fluorescent Nanoparticles for Bioimaging.
Article in Frontiers in chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Article
- Dual-color core-shell silica nanosystems for advanced super-resolution biomedical imaging.Nanoscale advances · 2023Article
- Brightness of fluorescent organic nanomaterials.Chemical Society reviews · 2023Review
- Effects of Cascading Optical Processes: Part III. Impacts on Spectroscopic Measurements of Fluorescent Samples.Analytical chemistry · 2023Article
- Research Progress and Future Trends of Microfluidic Paper-Based Analytical Devices in In-Vitro Diagnosis.Biosensors · 2022Review
- Nanoparticulate Photoluminescent Probes for Bioimaging: Small Molecules and Polymers.International journal of molecular sciences · 2022Review
- Review on Nanoparticles and Nanostructured Materials: Bioimaging, Biosensing, Drug Delivery, Tissue Engineering, Antimicrobial, and Agro-Food Applications.Nanomaterials (Basel, Switzerland) · 2022Review
- Synthesis and characterization of novel protein nanodots as drug delivery carriers with an enhanced biological efficacy of melatonin in breast cancer cells.RSC advances · 2021Article
- Adsorption of Cd to TiOCells · 2021Article
- Near-infrared fluorescence imaging in immunotherapy.Advanced drug delivery reviews · 2020Review
- Bio-Applications of Multifunctional Melanin Nanoparticles: From Nanomedicine to Nanocosmetics.Nanomaterials (Basel, Switzerland) · 2020Review
- Graphene oxide and its derivatives as promising In-vitro bio-imaging platforms.Scientific reports · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence is a powerful tool for mapping biological events in real-time with high spatial resolution. Ultra-bright probes are needed in order to achieve high sensitivity: these probes are typically obtained by gathering a huge number of fluorophores in a single nanoparticle (NP). Unfortunately this assembly produces quenching of the fluorescence because of short-range intermolecular interactions. Here we demonstrate that rational structural modification of a well-known molecular fluorophore N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl) (NBD) produces fluorophores that self-assemble in nanoparticles in the biocompatible environment without any dramatic decrease of the fluorescence quantum yield. Most importantly, the resulting NP show, in an aqueous environment, a brightness which is more than six orders of magnitude higher than the molecular component in the organic solvent. Moreover, the NP are prepared by nanoprecipitation and they are stabilized only via non-covalent interaction, they are surprisingly stable and can be observed as individual bright spots freely diffusing in solution at a concentration as low as 1 nM. The suitability of the NP as biocompatible fluorescent probes was demonstrated in the case of HeLa cells by fluorescence confocal microscopy and MTS assays.
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