ArticleJournal of family medicine and primary care2019
Effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis.
Article in Journal of family medicine and primary care, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Vitamin D deficiency in rheumatoid arthritis patients of India - a single-arm meta-analysis.African health sciences · 2023Pooled it
- Effect of Vitamin D Supplementation in Rheumatoid Arthritis.Advances in therapy · 2026Article
- The Effect of Vitamin D Supplementation on Clinical and Laboratory Biomarkers in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Mediterranean journal of rheumatology · 2025Article
- Impact of vitamin D supplementation on disease activity and pain management in rheumatoid arthritis: a randomized double-blinded controlled study.BMC rheumatology · 2025Article
- Effects of vitamin D supplementation in patients with rheumatoid arthritis: A systematic review and meta-analysis.Heliyon · 2025Review
- Seasonal and Treatment-Related Variation in 25-Hydroxy Vitamin D Concentration in Patients with Rheumatoid Arthritis.Journal of clinical medicine · 2024Article
- The effects of vitamin D supplementation on disease activity and fatigue in Libyan rheumatoid arthritis patients.Reumatologia · 2024Article
- Involvement of the secosteroid vitamin D in autoimmune rheumatic diseases and COVID-19.Nature reviews. Rheumatology · 2023Review
- Vitamin D and Autoimmune Rheumatic Diseases.Biomolecules · 2023Review
- Vitamin D deficiency: concern for rheumatoid arthritis and COVID-19?Molecular and cellular biochemistry · 2021Review
- The Effects of Vitamin D on Immune System and Inflammatory Diseases.Biomolecules · 2021Review
- A bioavailable form of curcumin, in combination with vitamin-D- and omega-3-enriched diet, modifies disease onset and outcomes in a murine model of collagen-induced arthritis.Arthritis research & therapy · 2021Article
- Lower concentration of vitamin D is associated with lower DAS28 and VAS-pain scores in patients with inflammatory rheumatic diseases treated with infliximab: a pilot study.Rheumatology international · 2020Observational
- 1,25-dihydroxy Vitamin D3 and Interleukin-6 Blockade Synergistically Regulate Rheumatoid Arthritis by Suppressing Interleukin-17 Production and Osteoclastogenesis.Journal of Korean medical science · 2020Article
- Additive Effects of VDBP and 1,25(OH)2D3 on the Viability and Apoptosis of Rheumatoid Arthritis Synovial Fibroblasts.Frontiers in endocrinology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo assess effect of 1,25 dihydroxy vitamin D3 supplementation on pain relief in early rheumatoid arthritis (RA). MATERIALS AND
methodsAn open-labeled randomized trial was conducted comparing 60,000 IU 1,25 dihydroxy vitamin D3 + calcium (1000 mg/day) combination [Group A] versus calcium (1000 mg/day) only [Group B], as supplement to existing treatment regimen in early RA. Primary outcome included (i) minimum time required for onset of pain relief (Tm) assessed through patients' visual analog scale (VAS); (ii) % change in VAS score from onset of pain relief to end of 8 weeks. Secondary outcome included change in disease activity score (DAS-28).
resultsAt the end of 8-weeks, Group A reported 50% higher median pain relief scores (80% vs. 30%;
conclusionsVitamin-D deficiency is a risk factor for developing active disease in RA. Weekly supplementation of 60,000 IU of 1,25 dihydroxy vitamin D3 in early RA results in greater pain relief. The number needed to treat for this additional pain relief was 2. IDENTIFIER: CTRI/2018/01/011532 (www.ctri.nic.in).
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