ArticleAvicenna journal of phytomedicine
Phytochemical composition, and cytotoxic, antioxidant, and antibacterial activity of the essential oil and methanol extract of
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 19 citations in OpenAlex.
- Nanosponge-integrated hydrogel ofFrontiers in pharmacology · 2026Article
- Comparative Analysis of Volatile Compounds and Biochemical Activity ofPlants (Basel, Switzerland) · 2024Article
- Production of biosurfactant by salt-resistant Bacillus in lead-supplemented media: application and toxicity.International microbiology : the official journal of the Spanish Society for Microbiology · 2023Article
- Natural essential oils as a new therapeutic tool in colorectal cancer.Cancer cell international · 2022Review
- Chemical composition, anticancer and antibacterial activity of Nepeta mahanensis essential oil.BMC complementary medicine and therapies · 2022Article
- Health Benefits, Pharmacological Effects, Molecular Mechanisms, and Therapeutic Potential of α-Bisabolol.Nutrients · 2022Review
- Article
- P-cymene prevent high-fat diet-associated colorectal cancer by improving the structure of intestinal flora.Journal of Cancer · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this study, our aim was to extract, and identify and quantify the chemical composition of essential oils of MATERIALS AND
methodsGC and GC/MS analysis were used for identifying and quantifying the essential oil components. Antioxidant and antibacterial activity were tested by 2, 2-diphenyl-1-picrylhydrazyl (DPPH) and agar disc diffusion methods, respectively and MTT assay was used to determine the anti-proliferative potential of the oil against breast (MCF-7), colon (HT-29), neuroblastoma (SH-SY5Y), embryonal carcinoma (NCCIT) cancer cell relative to human umbilical vein endothelial cell (HUVEC) as a normal cell. Apoptosis induction was monitored by flow cytometry using PE annexin V apoptosis detection kit and cell cycle arrest was by with propidium iodide.
resultsZ-β-ocimene (25.1%), linalool (17.8%) and β-bisabolol (13.3%) were recognized as major components of the essential oil. Our study demonstrated apoptosis-inducing potential of essential oil on normal and cancer cells. However, methanol extract exerted cytotoxicity against a number of cancer cells and arrested cancer cells in G2/M phase; nevertheless, it did not exert strong cytotoxicity against normal cells. Furthermore, DPPH and disc diffusion results showed that while essential oil has considerable antiradical activity, methanol extract did not exert promising antioxidant and antimicrobial activity.
conclusionMethanol extract of
Indexed as
Identifiers
30984579PMC6448547W2904175569What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.