Evidence map›Paper›PMID 30984517›Full record

ArticleCurrent stem cell reports2018

Dynamic regulation of hematopoietic stem cells by bone marrow niches.

Margot May, Anastasiya Slaughter, Daniel Lucas

Abstract read
In one paragraph

Article in Current stem cell reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. Epithelial-Mesenchymal Transition in Acute Leukemias.International journal of molecular sciences · 2024
    Review
  4. Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Margot May *Department of Cell and Developmental Biology. University of Michigan School of Medicine. Ann Arbor. Michigan, USA.
Anastasiya Slaughter *Division of Experimental Hematology and Cancer Biology. Cincinnati Children's Medical Center. 240 Albert Sabin Way, Floor S7.351, Cincinnati, OH 45229.
Daniel LucasDivision of Experimental Hematology and Cancer Biology. Cincinnati Children's Medical Center. 240 Albert Sabin Way, Floor S7.351, Cincinnati, OH 45229.

Funding

Cellular crosstalk in the hematopoietic microenvironmentR01HL136529 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI LUCAS, DANIEL · 2018 to 2021
$1.6M
NHLBI NIH HHS R01 HL136529
6 · The paper itself

Abstract

purpose of reviewHematopoietic stem cells (HSC) reside in a specialized microenvironment called the HSC niche. While key components of the niche have been known for several years, recent advances have identified several additional cell types that regulate HSC in the bone marrow (BM). Here we review our current understanding of the components and dynamics of the HSC niche. RECENT

findingsWhile the niche has been considered a stable structure, recent advances clearly show that the niche is regulated in a dynamic manner to control HSC traffic and function. Moreover the niche can rapidly remodel in response to insults to the BM in a process controlled by positive and negative regulators. SUMMARY: Multiple niche cells have been shown to be dynamically regulated by systemic and local signals to influence how the niche controls HSC function. Elucidating how different components of the niche coordinate to orchestrate HSC behavior is essential to understand how the hematopoietic system adjusts blood cell production to the demands of the body.

Indexed as

dynamicHematopoietic stem cellnicheplasticity

Identifiers

PMID30984517
PMCPMC6456047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.