ReviewGlobal spine journal2019
Local and Distant Recurrence in Resected Sacral Chordomas: A Systematic Review and Pooled Cohort Analysis.
Review in Global spine journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- A surgical case of posterior mediastinum chordoma requiring differentiation from neurogenic tumor.General thoracic and cardiovascular surgery cases · 2026Article
- Case Report: Multilevel spondylectomy for en bloc resection of an upper cervical chordoma: surgical technique and conceptualization through the CLiMR framework.Frontiers in oncology · 2026Article
- Metastatic sacral chordoma presenting as a cecal polyp: a case report.Journal of surgical case reports · 2025Article
- Comparative Outcomes of Brachyury Vaccine vs. Imatinib in Advanced Chordoma: A Mayo Clinic Experience.Cancers · 2025Article
- Cervical chordoma en bloc resection and staged suprascapular nerve transfer reanimation: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Multidisciplinary En-Bloc Resection of Sacral Chordoma: A Narrative Review and Illustrative Case.Journal of clinical medicine · 2025Review
- Layered Repair in Extensive Sacral Defects with Bilaminar Gluteal Flaps: Demirdover Flaps.Plastic and reconstructive surgery. Global open · 2025Article
- Characteristics and survival outcomes in pediatric patients with spinal chordomas: insights from the National Cancer Database and review of the literature.Journal of neuro-oncology · 2025Review
- B7-H3 CAR-T cell therapy combined with irradiation is effective in targeting bulk and radiation-resistant chordoma cancer cells.Journal for immunotherapy of cancer · 2025Article
- Sacral Resections for Primary Sacral Tumor - an Experience from a Tertiary Care Cancer Center in India.Indian journal of surgical oncology · 2024Article
- Clinical Outcome after Surgical Treatment of Sacral Chordomas: A Single-Center Retrospective Cohort of 27 Patients.Cancers · 2024Article
- A retrospective study on the mechanism underlying quick transfer from response to resistance in a repeated recurrent chordoma patient with molecular alterations treated with Palbociclib.Journal of cancer research and clinical oncology · 2024Article
- Chordoma: demographics and survival analysis with a focus on racial disparities and the role of surgery, a U.S. population-based study.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2024Article
- Intensity-modulated radiotherapy for the management of primary and recurrent chordomas: a retrospective long-term follow-up study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2023Article
- En bloc resection of a high cervical chordoma followed by reconstruction with a free vascularized fibular graft: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Survival and treatment of cranial and spinal chordomas: a population-based study.Neurosurgical review · 2022Article
- Partial sacrectomy with patient-specific osteotomy guides.North American Spine Society journal · 2021Article
- Article
- A case-control study of computer navigation assisted resection of primary sacral chordoma above sacrum 3 level.Journal of bone oncology · 2020Article
- Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
designSystematic review.
objectivesSacral chordomas are rare, primary tumors of the spine, best treated with en bloc resection. The purpose of this study was to assess the literature for resected sacral chordoma and to quantify the prevalence of, risk factors for, and treatment outcomes of local and distant recurrence therein.
methodsWe searched 5 online databases from January 1980 to May 2016 to find articles that report survival, recurrence outcomes, and/or prognostic factors for the resected sacral chordoma patient population. Characteristics and clinical outcomes of the pooled cohort are reported. Fisher exact tests, unpaired
resultsFifty-seven studies, with 1235 unique sacral chordoma patients, were included in this review. Local and distant recurrence occurred in 42.6% and 22.4% of patients with adequate follow-up, respectively. Kaplan-Meier overall median survival for patients with and without recurrence were 98 and 209 months after surgery, respectively. Wide surgical margin was associated with a lower rate of local recurrence; and wide surgical margin, female sex, and patient age ≥65 years were associated with lower rates of distant recurrence.
conclusionsWhile surgical margin remains the most significant prognostic factor for local and distant recurrence, combined surgical approach may be associated with local recurrence. Male sex and age <65 years may be associated with distant recurrence. Patients with risk factors for recurrence should undergo close monitoring to maximize survival.
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