ArticleWorld journal of gastrointestinal oncology2019
Gut-associated lymphoid tissue or so-called "dome" carcinoma of the colon: Review.
Article in World journal of gastrointestinal oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 14 citations in OpenAlex.
- GALT/Dome Adenocarcinoma in a Patient With MLH1-Deficient Lynch Syndrome: Navigating a Clinical and Management Dilemma.ACG case reports journal · 2026Article
- A Rare Case of Colon Cancer Presenting as a Submucosal Mass.Digestive diseases and sciences · 2026Article
- Redefining GALT-associated carcinoma: a distinct subtype of colorectal adenocarcinoma.Virchows Archiv : an international journal of pathology · 2026Article
- Lymphoglandular Complex-Like Colorectal Carcinoma Arising in Tubular Adenoma: A Case Report.Cureus · 2026Article
- Family adenomatous polyposis come across dome type adenocarcinoma: a case report and literature review.Diagnostic pathology · 2025Review
- Rare Case of Gut-associated Lymphoid Tissue Carcinoma in the Sigmoid Colon of a Very Elderly Patient: A Case Report.Journal of the anus, rectum and colon · 2025Article
- Molecular profiling of the intestinal mucosa and immune cells of the colon by multi-parametric histological techniques.Scientific reports · 2021Article
- A Focused Review on Advances in Risk Stratification of Malignant Polyps.Gastroenterology research · 2020Review
- A case of a rectal adenocarcinoma mimicking a neuroendocrine tumor in the background mucosa of amoebic colitis.Clinical journal of gastroenterology · 2020Article
- Colorectal epithelial neoplasm associated with gut-associated lymphoid tissue.Journal of pathology and translational medicine · 2020Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo present a comprehensive review of the etiology, clinical features, macroscopic and pathological findings, and clinical significance of Gut-associated lymphoid tissue or "dome" carcinoma of the colon.
methodsThe English language medical literature on gut- or gastrointestinal-associated lymphoid tissue (GALT) or "dome" carcinoma of the colon was searched and appraised.
resultsGALT/dome-type carcinomas of the colon are thought to arise from the M-cells of the lymphoglandular complex of the intestine. They are typically asymptomatic and have a characteristic endoscopic plaque- or "dome"-like appearance. Although the histology of GALT/dome-type carcinomas displays some variability, they are characterized by submucosal localization, a prominent lymphoid infiltrate with germinal center formation, tumor-infiltrating lymphocytes, absence of desmoplasia, and dilated glands lined by columnar epithelial cells with bland nuclear features and cytoplasmic eosinophilia. None of the patients reported in the literature with follow-up have developed metastatic disease or local recurrence.
conclusionIncreased awareness amongst histopathologists of this variant of colorectal adenocarcinoma is likely to lead to the recognition of more cases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.