ReviewThe EPMA journal2019
Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach.
Review in The EPMA journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
45 citing papers in PubMed, 73 citations in OpenAlex.
- Young-onset stroke in the UAE: A single-centre retrospective analysis of risk factors and outcomes.PloS one · 2026Article
- Association of Obesity and Body Composition and Hospitalization Risk with Infection in the CRIC Study.Clinical journal of the American Society of Nephrology : CJASN · 2025Article
- How to use an extensive Flammer syndrome phenotyping for a holistic protection against health-to-disease transition - facts and practical recommendations.The EPMA journal · 2025Article
- Acute mountain sickness prediction: a concerto of multidimensional phenotypic data and machine learning strategies in the framework of predictive, preventive, and personalized medicine.The EPMA journal · 2025Article
- Changes in the metabolic score for insulin resistance index for risk prediction of stroke in middle-aged and older Chinese population.The EPMA journal · 2024Article
- Body fluid multiomics in 3PM-guided ischemic stroke management: health risk assessment, targeted protection against health-to-disease transition, and cost-effective personalized approach are envisaged.The EPMA journal · 2024Review
- Mini-encyclopedia of mitochondria-relevant nutraceuticals protecting health in primary and secondary care-clinically relevant 3PM innovation.The EPMA journal · 2024Article
- Role of decompressive craniectomy in the management of acute ischemic stroke (Review).Biomedical reports · 2024Review
- Factors associated with self-management behaviors among Chinese adults with ischemic stroke: A cross-sectional study.Belitung nursing journal · 2024Article
- Overview of the Association Between the Pathophysiology, Types, and Management of Sickle Cell Disease and Stroke.Cureus · 2023Review
- Diabetes, glycemic control and arterial stiffness: a real-world cohort study in the context of predictive, preventive, and personalized medicine.The EPMA journal · 2023Article
- Comprehensive analysis of mitochondrial dysfunction and necroptosis in intracranial aneurysms from the perspective of predictive, preventative, and personalized medicine.Apoptosis : an international journal on programmed cell death · 2023Article
- Subtyping Patients With Chronic Disease Using Longitudinal BMI Patterns.IEEE journal of biomedical and health informatics · 2023Article
- Ischemic Stroke in the Setting of Anabolic Androgenic Steroid Use.Kansas journal of medicine · 2023Article
- Mutual effect of homocysteine and uric acid on arterial stiffness and cardiovascular risk in the context of predictive, preventive, and personalized medicine.The EPMA journal · 2022Article
- Pre-pregnancy check-up of maternal vascular status and associated phenotype is crucial for the health of mother and offspring.The EPMA journal · 2022Article
- Relationship Between Cerebrovascular Diseases and Vasculitis: A Cross-Sectional Nationwide Inpatient Study.Cureus · 2022Article
- Rapid triage for ischemic stroke: a machine learning-driven approach in the context of predictive, preventive and personalised medicine.The EPMA journal · 2022Article
- Mitochondrial health quality control: measurements and interpretation in the framework of predictive, preventive, and personalized medicine.The EPMA journal · 2022Review
- Clinical Characteristics and Gene Mutation Analysis of Poststroke Epilepsy.Contrast media & molecular imaging · 2022Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is one of the most devastating pathologies of the early twenty-first century demonstrating 1-month case-fatality rates ranging from 13 to 35% worldwide. Though the majority of cases do occur in individuals at an advanced age, a persistently increasing portion of the patient cohorts is affected early in life. Current studies provide alarming statistics for the incidence of "young" strokes including adolescents. Young stroke is a multifactorial disease involving genetic predisposition but also a number of modifiable factors, the synergic combination of which potentiates the risks. The article analyzes the prevalence and impacts of "traditional" risk factors such as sedentary lifestyle, smoking, abnormal alcohol consumption, drug abuse, overweight, hypertension, abnormal sleep patterns, and usage of hormonal contraceptives, among others. Further, less explored risks such as primary vascular dysregulation and associated symptoms characteristic for Flammer syndrome (FS) are considered, and the relevance of the FS phenotype for the stroke predisposition at young age is hypothesized. Considering the high prevalence of known genetic and modifiable risk factors in the overall predisposition to the young stroke, the risk mitigating measures are recommended including innovative screening programs by application of specialized questionnaires and biomarker panels as well as educational programs adapted to the target audiences such as children, adolescents, and young adults.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.