ArticleNature physics2019
Large-scale curvature sensing by directional actin flow drives cellular migration mode switching.
Article in Nature physics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 104 citations in OpenAlex.
- Cell shapes decode molecular phenotypes in image-based spatial proteomics.Cell systems · 2026Article
- Physical models of embryonic epithelial healing.PLoS computational biology · 2026Review
- Mathematical Prediction for Geometry-Mediated Cell 3D In-Growth on Bone Tissue Engineering Scaffolds.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanocollision promotes locomotion of dendritic cells for tumor therapy.Science advances · 2026Article
- Geometrical Designs in Volumetric Bioprinting to Study Cellular Behaviors in Engineered Constructs.Advanced healthcare materials · 2026Article
- Physical Frameworks and Theories on How Autonomous Biological Oscillators Synchronize.Advances in experimental medicine and biology · 2026Review
- Mechanosensitive dynamics of lysosomes along microtubules regulate leader cell emergence during collective cell migration.Nature communications · 2025Article
- Regulation of corneal stromal cell behavior by modulating curvature using a hydraulically-controlled organ chip array.Nature communications · 2025Article
- Unlocking the therapeutic potential of cellular mechanobiology.Science advances · 2025Review
- Myoblast Choreographic Alignment.ACS nano · 2025Article
- Edge curvature drives endoplasmic reticulum reorganization and dictates epithelial migration mode.Nature cell biology · 2025Article
- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Epithelial Layer Fluidization by Curvature-Induced Unjamming.Physical review letters · 2025Article
- The Mechanics of Building Functional Organs.Cold Spring Harbor perspectives in biology · 2025Review
- A minimal physical model for curvotaxis driven by curved protein complexes at the cell's leading edge.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Squishy matters - Corneal mechanobiology in health and disease.Progress in retinal and eye research · 2024Review
- Alteration of actin cytoskeletal organisation in fetal akinesia deformation sequence.Scientific reports · 2024Article
- Regeneration in calcareous sponge relies on 'purse-string' mechanism and the rearrangements of actin cytoskeleton.Cell and tissue research · 2023Article
- Switch of cell migration modes orchestrated by changes of three-dimensional lamellipodium structure and intracellular diffusion.Nature communications · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 7 institutions in 5 countries.
Funding
Abstract
Cell migration over heterogeneous substrates during wound healing or morphogenetic processes leads to shape changes driven by different organizations of the actin cytoskeleton and by functional changes including lamellipodial protrusions and contractile actin cables. Cells distinguish between cell-sized positive and negative curvatures in their physical environment by forming protrusions at positive ones and actin cables at negative ones; however, the cellular mechanisms remain unclear. Here, we report that concave edges promote polarized actin structures with actin flow directed towards the cell edge, in contrast to well-documented retrograde flow at convex edges. Anterograde flow and contractility induce a tension anisotropy gradient. A polarized actin network is formed, accompanied by a local polymerization-depolymerization gradient, together with leading-edge contractile actin cables in the front. These cables extend onto non-adherent regions while still maintaining contact with the substrate through focal adhesions. The contraction and dynamic reorganization of this actin structure allows forward movements enabling cell migration over non-adherent regions on the substrate. These versatile functional structures may help cells sense and navigate their environment by adapting to external geometric and mechanical cues.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.