Evidence map›Paper›PMID 30984232›Full record

ArticleFrontiers in genetics2019

Identification of a Functional Non-coding Variant in the GABA

Megan K Mulligan, Timothy Abreo, Sarah M Neuner, Cory Parks, Christine E Watkins, M Trevor Houseal, Thomas M Shapaker, Michael Hook, Haiyan Tan, Xusheng Wang and 7 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in genetics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
14.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 64 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 5 institutions in 1 country.

Megan K MulliganDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Timothy AbreoDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Sarah M NeunerDepartment of Anatomy and Neurobiology, University of Tennessee Health Science Center, Memphis, TN, United States.
Cory ParksDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Christine E WatkinsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
M Trevor HousealDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Thomas M ShapakerDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Michael HookDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Haiyan TanDepartments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, United States.
Xusheng WangDepartments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, United States.
Jesse IngelsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Junmin PengDepartments of Structural Biology and Developmental Neurobiology, Center for Proteomics and Metabolomics, St. Jude Children's Research Hospital, Memphis, TN, United States.
Lu LuDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
Catherine C KaczorowskiThe Jackson Laboratory, Bar Harbor, ME, United States.
Camron D BryantLaboratory of Addiction Genetics, Department of Pharmacology and Experimental Therapeutics and Psychiatry, Boston University School of Medicine, Boston, MA, United States.
Gregg E HomanicsDepartments of Anesthesiology and Perioperative Medicine, Neurobiology, and Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, PA, United States.
Robert W WilliamsDepartment of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States.
University of Tennessee Health Science Center · USSt. Jude Children's Research Hospital · USJackson Laboratory · USBoston University · USUniversity of Pittsburgh · US

Funding

Role of noncoding RNA in alcohol actionU01AA020889 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sean P Farris, Gregg E. Homanics · 2011 to 2026
$7.1M
Systems Genetics of Alcohol Response and Stress Effects in CNSU01AA013499 · NIAAA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI WILLIAMS, ROBERT W. · 2002 to 2016
$4.8M
Ethanol Mechanisms in GABAAR Gene Targeted MiceR37AA010422 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOMANICS, GREGG E. · 2010 to 2019
$4.4M
ETHANOL MECHANISMS IN GABAAR GENE TARGETED MICER01AA010422 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HOMANICS, GREGG E. · 1995 to 2008
$3.1M
Bridging genetic variation with behavior: Molecular and functional mechanisms of quantitative trait gene regulation of the stimulant and addictive properties of methamphetamine in miceR01DA039168 · NIDA · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BRYANT, CAMRON D · 2015 to 2019
$3.0M
INIA-STRESS: Informatics and Analysis CoreU01AA016662 · NIAAA · VIRGINIA COMMONWEALTH UNIVERSITY · PI WILLIAMS, ROBERT W. · 2007 to 2016
$2.9M
LNCRNA REGULATION OF GENE EXPRESSION & BEHAVIORR01AA030257 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sean P Farris · 2022 to 2026
$2.8M
RNA splicing dysfunction in Alzheimer's diseaseR01AG047928 · NIA · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI PENG, JUNMIN · 2015 to 2019
$1.8M
Genetic basis of chemotherapy-induced neuropathy in a reduced complexity crossR01CA221260 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI BRYANT, CAMRON D, DAMAJ, M. IMAD · 2018 to 2021
$1.7M
Mapping AD Memory Failure: Molecules to Connectivity of Brain NetworkR21AG048446 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI KACZOROWSKI, CATHERINE COOK · 2015 to 2016
$418k
Identification of Genetic Modifiers of Neuronal Deficits and Memory Failure in Alzheimers DiseaseF31AG050357 · NIA · UNIVERSITY OF TENNESSEE HEALTH SCI CTR · PI NEUNER, SARAH M · 2015 to 2018
$171k
NCI NIH HHS R01 CA221260NIAAA NIH HHS R01 AA010422NIAAA NIH HHS R01 AA030257NIAAA NIH HHS R37 AA010422NIAAA NIH HHS U01 AA013499NIAAA NIH HHS U01 AA016662NIAAA NIH HHS U01 AA020889NIA NIH HHS F31 AG050357NIA NIH HHS R01 AG047928NIA NIH HHS R21 AG048446NIDA NIH HHS R01 DA039168
6 · The paper itself

Abstract

GABA type-A (GABA-A) receptors containing the α2 subunit (GABRA2) are expressed in most brain regions and are critical in modulating inhibitory synaptic function. Genetic variation at the

Indexed as

BXD mice strainsC57BL/6JCRISPR (clustered regularly interspaced short palindromic repeats)/Cas9GABA-A receptorGABRA2geneticsinbred mouse strainsneuroscience

Identifiers

PMID30984232
PMCPMC6449455
OpenAlexW2949406235

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.