Evidence map›Paper›PMID 30984199›Full record

ArticleFrontiers in immunology2019

CSF Free Light Chains as a Marker of Intrathecal Immunoglobulin Synthesis in Multiple Sclerosis: A Blood-CSF Barrier Related Evaluation in a Large Cohort.

Makbule Senel, Fatemeh Mojib-Yezdani, Ulrike Braisch, Franziska Bachhuber, Jan Lewerenz, Albert C Ludolph, Markus Otto, Hayrettin Tumani

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Makbule SenelDepartment of Neurology, University of Ulm, Ulm, Germany.
Fatemeh Mojib-YezdaniDepartment of Neurology, University of Ulm, Ulm, Germany.
Ulrike BraischInstitute of Epidemiology and Medical Biometry, Ulm University, Ulm, Germany.
Franziska BachhuberDepartment of Neurology, University of Ulm, Ulm, Germany.
Jan LewerenzDepartment of Neurology, University of Ulm, Ulm, Germany.
Albert C LudolphDepartment of Neurology, University of Ulm, Ulm, Germany.
Markus OttoDepartment of Neurology, University of Ulm, Ulm, Germany.
Hayrettin TumaniDepartment of Neurology, University of Ulm, Ulm, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Immunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsMultiple SclerosisAdultAgedBiomarkersCross-Sectional StudiesFemaleHumansImmunoglobulin GMaleMiddle AgedBiomarkersImmunoglobulin GImmunoglobulin kappa-ChainsImmunoglobulin lambda-Chainscerebrospinal fluidIgG indeximmunoglobulin free light chainsintrathecal IgG synthesismultiple sclerosisOCBoligoclonal bandsserum

Identifiers

PMID30984199
PMCPMC6449445

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.