Evidence map›Paper›PMID 30984185›Full record

ReviewFrontiers in immunology2019

Considering Abundance, Affinity, and Binding Site Availability in the NF-κB Target Selection Puzzle.

Ruth Brignall, Amy T Moody, Shibin Mathew, Suzanne Gaudet

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 38 citations in OpenAlex.

  1. bioRxiv : the preprint server for biology · 2025
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  17. Transcription factor NF-κB unravels nucleosomes.Biochimica et biophysica acta. General subjects · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Ruth BrignallCenter for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States.
Amy T MoodyCenter for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States.
Shibin MathewCenter for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States.
Suzanne GaudetCenter for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, United States.
Dana-Farber Cancer Institute · USBoston VA Research Institute · USTufts University · US

Funding

Single-cell analysis of TNF-induced signaling, transcription and fate decisionsR01GM104247 · NIGMS · DANA-FARBER CANCER INST · PI GAUDET, SUZANNE · 2013 to 2017
$1.7M
Signaling dynamics and cellular context as drivers of the heterogeneity of macrophage infection by M. tuberculosisF32AI136422 · NIAID · DANA-FARBER CANCER INST · PI MOODY, AMY THURBER · 2018 to 2018
$25k
NIAID NIH HHS F32 AI136422NIGMS NIH HHS R01 GM104247
6 · The paper itself

Abstract

The NF-κB transcription regulation system governs a diverse set of responses to various cytokine stimuli. With tools from

Indexed as

AnimalsGene Expression RegulationHumansNF-kappa BResponse ElementsTranscription, GeneticNF-kappa BaccessibilitycompetitionNF-κBspecificitytranscription regulation

Identifiers

PMID30984185
PMCPMC6450194
OpenAlexW2927664050

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.