Evidence map›Paper›PMID 30984180›Full record

ArticleFrontiers in immunology2019

1,25-Dihydroxyvitamin D

Louise Saul, Iris Mair, Alasdair Ivens, Pamela Brown, Kay Samuel, John D M Campbell, Daniel Y Soong, Nadine Kamenjarin, Richard J Mellanby

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. RNA Flow Cytometry for the Study of T Cell Metabolism.International journal of molecular sciences · 2021
    Review
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  15. Review
  16. Article
  17. Modulating effect of vitamin D3 on the mutagenicity and carcinogenicity of doxorubicin in Drosophila melanogaster and in silico studies.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2020
    Article
  18. Review
  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Louise SaulMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Iris MairMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Alasdair IvensAshworth Laboratories, Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh, United Kingdom.
Pamela BrownBiomolecular Core, MRC Centre for Reproductive Health, Queen's Medical Research Institute, Shared University Research Facility, University of Edinburgh, Edinburgh, United Kingdom.
Kay SamuelScottish National Blood Transfusion Service, Edinburgh, United Kingdom.
John D M CampbellScottish National Blood Transfusion Service, Edinburgh, United Kingdom.
Daniel Y SoongMRC Centre for Reproductive Health, Queen's Medical Research Institute, Edinburgh, United Kingdom.
Nadine KamenjarinMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Richard J MellanbyMRC Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom.
Queen's Medical Centre · GBScottish National Blood Transfusion Service · GBCentre for Immunity, Infection and Evolution · GBCentre for Inflammation Research · GBMRC Centre for Reproductive Health · GBUniversity of Edinburgh · GB

Funding

Medical Research Council MR/K001744/1Medical Research Council MR/N022556/1Wellcome Trust
6 · The paper itself

Abstract

Dendritic cells (DC) are specialized sentinel cells that bridge the innate and adaptive immune response and play a crucial role in shaping the adaptive immune response. Vitamin D, a known epidemiological risk factor for the development of several autoimmune diseases, influences the development of dendritic cells. Consequently, vitamin D metabolites are frequently used in protocols to develop therapeutic dendritic cell therapies for autoimmune diseases. However, the mechanisms by which vitamin D modulates DC function remain poorly understood. We investigated the effects of vitamin D on murine CD11c

Indexed as

AnimalsCD11c AntigenCD4-Positive T-LymphocytesDendritic CellsFemaleHumansMice, TransgenicPlatelet Endothelial Cell Adhesion Molecule-1Up-RegulationVitamin DVitamins1,25-dihydroxyvitamin DCD11c AntigenPlatelet Endothelial Cell Adhesion Molecule-1Vitamin DVitamins125(OH)2D3autoimmune diseaseCD31dendritic cellsT cell primingvitamin D

Identifiers

PMID30984180
PMCPMC6447667
OpenAlexW2933547532

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.