ArticleFrontiers in immunology2019
The Fish-Specific Protein Kinase (PKZ) Initiates Innate Immune Responses via IRF3- and ISGF3-Like Mediated Pathways.
Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Effects of Chlorantraniliprole on Oxidative Stress, Enzymatic Biomarkers, and Hepatic Transcriptome inInternational journal of molecular sciences · 2026Article
- Transcriptome Analysis and Hub Gene Identification in the Brain Cell Lines of the Spotted Knifejaw (International journal of molecular sciences · 2026Article
- Fish Brain Cell Lines Can Be Infected with Adenoviral Vectors and Support Transgene Expression-An In Vitro Approach.International journal of molecular sciences · 2024Article
- Stressing out-carp edema virus induces stress and modulates immune response in common carp.Frontiers in immunology · 2024Article
- Z-RNA biology: a central role in the innate immune response?RNA (New York, N.Y.) · 2023Review
- Grass Carp Mex3A Promotes Ubiquitination and Degradation of RIG-I to Inhibit Innate Immune Response.Frontiers in immunology · 2022Article
- Grass Carp (Frontiers in immunology · 2021Article
- cGAS-STING pathway in cancer biotherapy.Molecular cancer · 2020Review
- The Role of the Z-DNA Binding Domain in Innate Immunity and Stress Granules.Frontiers in immunology · 2020Review
- PKZ, a Fish-Unique eIF2α Kinase Involved in Innate Immune Response.Frontiers in immunology · 2020Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PKZ is a fish-specific protein kinase containing Zα domains. PKZ is known to induce apoptosis through phosphorylating eukaryotic initiation factor 2α kinase (eIF2α) in the same way as double-stranded RNA-dependent protein kinase (PKR), but its exact role in detecting pathogens remains to be fully elucidated. Herein, we have found that PKZ acts as a fish-specific DNA sensor by initiating IFN expression through IRF3- or ISGF3-like mediated pathways. The expression pattern of
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