Evidence map›Paper›PMID 30984162›Full record

ArticleFrontiers in immunology2019

Shailesh K Shahi, Samantha N Freedman, Alexandra C Murra, Kasra Zarei, Ramakrishna Sompallae, Katherine N Gibson-Corley, Nitin J Karandikar, Joseph A Murray, Ashutosh K Mangalam

Open access · goldAbstract readComparative Study
In one paragraph

Article in Frontiers in immunology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 3 pooled it
6.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 3 syntheses or guidelines pooled it, 132 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Trial
  6. Bridging the gap:Gut microbes · 2026
    Review
  7. Article
  8. Journal of bacteriology · 2026
    Review
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Shailesh K ShahiDepartment of Pathology, University of Iowa, Iowa City, IA, United States.
Samantha N FreedmanGraduate Program in Immunology, University of Iowa, Iowa City, IA, United States.
Alexandra C MurraDepartment of Pathology, University of Iowa, Iowa City, IA, United States.
Kasra ZareiMedical Scientist Training Program, University of Iowa, Iowa City, IA, United States.
Ramakrishna SompallaeDepartment of Pathology, University of Iowa, Iowa City, IA, United States.
Katherine N Gibson-CorleyDepartment of Pathology, University of Iowa, Iowa City, IA, United States.
Nitin J KarandikarDepartment of Pathology, University of Iowa, Iowa City, IA, United States.
Joseph A MurrayDepartment of Immunology, Mayo Clinic, Rochester, MN, United States.
Ashutosh K MangalamDepartment of Pathology, University of Iowa, Iowa City, IA, United States.
University of Iowa · USWinnMed · US

Funding

Pulmonary Toxicology Facility CoreP30ES005605 · NIEHS · UNIVERSITY OF IOWA · PI Jong Sung Kim · 1990 to 2026
$40.5M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM007337 · NIGMS · UNIVERSITY OF IOWA · PI GEYER, PAMELA K., LENTZ, STEVEN R · 1985 to 2020
$15.9M
PREDOCTORAL TRAINING PROGRAM IN IMMUNOLOGYT32AI007485 · NIAID · UNIVERSITY OF IOWA · PI Kevin L Legge · 1995 to 2026
$5.4M
Linking diet, gut microbiota and autoimmune disease: Bacteria induced phytoestrogen metabolites impact immune function in Experimental Autoimmune EncephalitisR01AI137075 · NIAID · UNIVERSITY OF IOWA · PI MANGALAM, ASHUTOSH KUMAR · 2018 to 2022
$2.0M
BLRD VA I01 BX003677NIAID NIH HHS R01 AI137075NIAID NIH HHS T32 AI007485NIDDK NIH HHS P30 DK054759NIEHS NIH HHS P30 ES005605NIGMS NIH HHS T32 GM007337
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system. We and others have shown that there is enrichment or depletion of some gut bacteria in MS patients compared to healthy controls (HC), suggesting an important role of the gut bacteria in disease pathogenesis. Thus, specific gut bacteria that are lower in abundance in MS patients could be used as a potential treatment option for this disease. In particular, we and others have shown that MS patients have a lower abundance of

Indexed as

PrevotellaAnimalsBrainEncephalomyelitis, Autoimmune, ExperimentalGastrointestinal MicrobiomeGlatiramer AcetateHLA-DR3 AntigenHumansImmunosuppressive AgentsMice, TransgenicMultiple SclerosisSpinal CordGlatiramer AcetateHLA-DR3 AntigenImmunosuppressive Agentsanimal modelCopaxone®experimental autoimmune encephalomyelitis (EAE)gut microbiomeHLA transgenic miceimmune responsemultiple sclerosisPrevotella histicola

Identifiers

PMID30984162
PMCPMC6448018
OpenAlexW2922876067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.