ReviewFrontiers in endocrinology2019
Knowledge Gaps and Emerging Research Areas in Intrauterine Growth Restriction-Associated Brain Injury.
Review in Frontiers in endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 70 citations in OpenAlex.
- Fetal brain development in fetal growth restriction using MRI: a systematic review.BMC pregnancy and childbirth · 2025Pooled it
- A systematic review on estimating population attributable fraction for risk factors for small-for-gestational-age births in 81 low- and middle-income countries.Journal of global health · 2022Pooled it
- Letter regarding 'the association between serum iodine concentration in the first trimester and foetal ultrasound biometric parameters and birth size among Chinese pregnant women'.Annals of medicine · 2026Article
- Intranasal stem cell treatment ameliorates neuroinflammation and myelin aberrations in fetal growth-restricted rat pups.Stem cells translational medicine · 2026Article
- Birthweight phenotype genotype mismatch in cardiometabolic programming.Communications medicine · 2026Article
- Evaluation of fetal brain development in growth restriction subtypes using brain MRI volume measurement.BMC pregnancy and childbirth · 2026Article
- Metabolic expenditure, neurodevelopment, and weight gain into early childhood after fetal growth restriction.Scientific reports · 2026Article
- Deep learning assessment of fetal brain maturation on 3D ultrasound volumes in early-onset fetal growth restriction.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2026Observational
- Psychological Experiences of Pregnant Women with Fetal Growth Restriction in China: A Qualitative Study.International journal of women's health · 2025Article
- An interdisciplinary fetal neonatal neurology collaborative promotes integrative life-course brain health.Frontiers in neurology · 2025Review
- Long-Term Neurologic Consequences following Fetal Growth Restriction: The Impact on Brain Reserve.Developmental neuroscience · 2025Review
- Impact of Pre-Gestational BMI and Gestational Weight Gain on Fetal Development Outcomes in Adolescent Pregnant Women.Journal of clinical medicine · 2024Article
- Hepatic and Skeletal Muscle Autophagy Marker Levels in Rat Models of Prenatal and Postnatal Protein Restriction.Nutrients · 2023Article
- Echocardiographic assessment of brain sparing in small-for-gestational age infants and association with neonatal outcomes.Scientific reports · 2023Article
- Acupuncture on intrauterine growth restriction associated brain injury: case study including use of magnetic resonance imaging.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2023Article
- Docosahexaenoic acid improves cognition and hippocampal pyroptosis in rats with intrauterine growth restriction.Heliyon · 2023Article
- Fetal Growth Restriction and Clinical Parameters of Newborns from HIV-Infected Romanian Women.Medicina (Kaunas, Lithuania) · 2023Article
- Complex Management of Nephrotic Syndrome and Kidney Failure during Pregnancy in a Type 1 Diabetes Patient: A Challenging Case.Journal of clinical medicine · 2022Article
- Nanomaterial Inhalation During Pregnancy Alters Systemic Vascular Function in a Cyclooxygenase-Dependent Manner.Toxicological sciences : an official journal of the Society of Toxicology · 2022Article
- The Update of Fetal Growth Restriction Associated with Biomarkers.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intrauterine growth restriction (IUGR) is a complex global healthcare issue. Concerted research and clinical efforts have improved our knowledge of the neurodevelopmental sequelae of IUGR which has raised the profile of this complex problem. Nevertheless, there is still a lack of therapies to prevent the substantial rates of fetal demise or the constellation of permanent neurological deficits that arise from IUGR. The purpose of this article is to highlight the clinical and translational gaps in our knowledge that hamper our collective efforts to improve the neurological sequelae of IUGR. Also, we draw attention to cutting-edge tools and techniques that can provide novel insights into this disorder, and technologies that offer the potential for better drug design and delivery. We cover topics including: how we can improve our use of crib-side monitoring options, what we still need to know about inflammation in IUGR, the necessity for more human post-mortem studies, lessons from improved integrated histology-imaging analyses regarding the cell-specific nature of magnetic resonance imaging (MRI) signals, options to improve risk stratification with genomic analysis, and treatments mediated by nanoparticle delivery which are designed to modify specific cell functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.