ReviewFrontiers in physiology2019
Revisiting the Role of Exercise Countermeasure on the Regulation of Energy Balance During Space Flight.
Review in Frontiers in physiology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Introducing the Concept of Exercise Holidays for Human Spaceflight - What Can We Learn From the Recovery of Bed Rest Passive Control Groups.Frontiers in physiology · 2022Pooled it
- Effects of Spaceflight on Musculoskeletal Health: A Systematic Review and Meta-analysis, Considerations for Interplanetary Travel.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Artificial gravity during prolonged bed rest preserves resting metabolic rate but not muscle function: Evidence from the BRACE study.The Journal of physiology · 2026Trial
- The search for the ultimate exercise countermeasure to preserve crew health and ensure mission success in long-duration spaceflight.Experimental physiology · 2026Review
- Women in space: A review of known physiological adaptations and health perspectives.Experimental physiology · 2026Review
- A multimodal EMG and IMU dataset for assessing the quality of exercises designed for spatially constrained environments.Data in brief · 2026Article
- Adjuvant pharmacological strategies for the musculoskeletal system during long-term space missions.British journal of clinical pharmacology · 2026Review
- Integrating 3D Osteocyte Culture, Microgravity Simulation, and Fluid Flow Reveals Mechanisms of Osteocyte Mechanosensation and Calcium Signaling Altered by Disuse.Biomolecules · 2025Article
- Physiological Changes in the Cardiovascular System During Space Flight - Current Countermeasures and Future Vision.Circulation reports · 2025Review
- Space exploration and lifestyle medicine: a narrative review of its implications for astronaut health and remote Earth-based environments.Frontiers in physiology · 2025Review
- Profiling muscle transcriptome in mice exposed to microgravity using gene set enrichment analysis.NPJ microgravity · 2024Article
- The human microbiome in space: parallels between Earth-based dysbiosis, implications for long-duration spaceflight, and possible mitigation strategies.Clinical microbiology reviews · 2024Review
- Long-term space missions' effects on the human organism: what we do know and what requires further research.Frontiers in physiology · 2024Review
- Smooth Muscle Actin as a Criterion for Gravisensitivity of Stomach and Jejunum in Laboratory Rodents.International journal of molecular sciences · 2023Article
- New frontiers in the measurement of energy metabolism.American journal of physiology. Endocrinology and metabolism · 2023Article
- Skeletal muscle gene expression dysregulation in long-term spaceflights and aging is clock-dependent.NPJ microgravity · 2023Article
- Preserving Ready-to-Eat Meals Using Microwave Technologies for Future Space Programs.Foods (Basel, Switzerland) · 2023Review
- D-Mannose prevents bone loss under weightlessness.Journal of translational medicine · 2023Article
- Are Skeletal Muscle Changes during Prolonged Space Flights Similar to Those Experienced by Frail and Sarcopenic Older Adults?Life (Basel, Switzerland) · 2022Review
- Effect of Exercise on Energy Expenditure and Body Composition in Astronauts Onboard the International Space Station: Considerations for Interplanetary Travel.Sports medicine (Auckland, N.Z.) · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A body mass loss has been consistently observed in astronauts. This loss is of medical concern since energy deficit can exacerbate some of the deleterious physiological changes observed during space flight including cardiovascular deconditioning, bone density, muscle mass and strength losses, impaired exercise capacity, and immune deficiency among others. These may jeopardize crew health and performance, a healthy return to Earth and mission's overall success. In the context of planning for planetary exploration, achieving energy balance during long-term space flights becomes a research and operational priority. The regulation of energy balance and its components in current longer duration missions in space must be re-examined and fully understood. The purpose of this review is to summarize current understanding of how energy intake, energy expenditure, and hence energy balance are regulated in space compared to Earth. Data obtained in both actual and simulated microgravity thus far suggest that the obligatory exercise countermeasures program, rather than the microgravity
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.