Evidence map›Paper›PMID 30983973›Full record

ArticleFrontiers in cellular neuroscience2019

PACAP-38 and PACAP(6-38) Degranulate Rat Meningeal Mast Cells

Sara Hougaard Pedersen, Sanne Hage la Cour, Kirstine Calloe, Frank Hauser, Jes Olesen, Dan Arne Klaerke, Inger Jansen-Olesen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Trial
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. PACAP versus CGRP in migraine: From mouse models to clinical translation.Cephalalgia : an international journal of headache · 2025
    Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Migraine Treatment: Towards New Pharmacological Targets.International journal of molecular sciences · 2023
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Sara Hougaard PedersenGlostrup Research Institute, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.
Sanne Hage la CourGlostrup Research Institute, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.
Kirstine CalloeDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.
Frank HauserCell and Neurobiology, Department of Biology, Faculty of Science, University of Copenhagen, Copenhagen, Denmark.
Jes OlesenGlostrup Research Institute, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.
Dan Arne KlaerkeDepartment of Veterinary and Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Frederiksberg C, Denmark.
Inger Jansen-OlesenGlostrup Research Institute, Danish Headache Center, Department of Neurology, Rigshospitalet Glostrup, Copenhagen, Denmark.
University of Copenhagen · DKRigshospitalet · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Infusion of pituitary adenylate cyclase activating peptide-38 (PACAP-38) provokes migraine attacks in migraineurs and headache in non-migraineurs. Adverse events like long-lasting flushing and heat sensation can be terminated with oral antihistamine treatment, indicating the involvement of mast cell activation after PACAP-infusion. Degranulation of rat peritoneal mast cells was provoked by several isoforms of PACAP

Indexed as

dura materMas-related G-protein coupled receptor member B3mast cellmigrainePAC1-receptorpituitary adenylate cyclase activating peptidetwo-electrode voltage clampXenopus laevis oocytes

Identifiers

PMID30983973
PMCPMC6447718
OpenAlexW2927019291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.