ArticleInternational journal of health sciences
Effect of chronic administration and withdrawal of caffeine on motor function, cognitive functions, anxiety, and the social behavior of BLC57 mice.
Article in International journal of health sciences. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Caffeine attenuates cisplatin induced microglial reactivity and cognitive dysfunction.Frontiers in molecular neuroscience · 2026Article
- Short- and long-term neurobehavioural impairments in mice offspring following chronic perinatal caffeine exposure and withdrawal.BMC neuroscience · 2025Article
- Risk factors for primary dysmenorrhea and the effect of complementary and alternative treatment methods: Sample from Corum, Turkey.International journal of health sciencesArticle
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe cognitive functions, motor coordination, and social behavior were studied in rodents after adding different doses of caffeine in their drinking water. METHODOLOGY: BLC57 mice were divided into four groups: Control (
resultsIn water maze, the latency to reach the platform was significantly shorter in Ch MD group compared to the control and the Ch HD groups. WD group showed the worst performance. RR results showed that the groups treated with caffeine performed poor in comparison to the control group where their latency to fall was significantly less. In the three-chamber test, the Ch MD group showed enhanced sociability (session 1) and social novelty behavior (session 2). On the other hand, both Ch HD and WD showed a lack in sociability and a deficit in social novelty. In the EPM, results showed that all caffeine administrated mice where more anxious than the control group.
conclusionWe concluded that chronic administration of caffeine in MD resulted in enhancement of spatial memory, motor functions, sociability, and social novelty. The anxiety in these animals was, however, increased. On the other hand, Ch HD caffeine had opposite effects on all the parameters except for anxiety.
Indexed as
Identifiers
30983940PMC6436450W2946697692What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.