Evidence map›Paper›PMID 30983864›Full record

ArticleTurkish journal of biology = Turk biyoloji dergisi2018

Comparative study of mesenchymal stem cells from rat bone marrow and adipose tissue.

Qing He, Zhaoyang Ye, Yan Zhou, Wen-Song Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Turkish journal of biology = Turk biyoloji dergisi, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Qing HeState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology , Shanghai , P.R. China.
Zhaoyang YeState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology , Shanghai , P.R. China.ORCID 0000-0001-5136-2384
Yan ZhouState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology , Shanghai , P.R. China.ORCID 0000-0002-9205-9936
Wen-Song TanState Key Laboratory of Bioreactor Engineering, East China University of Science and Technology , Shanghai , P.R. China.ORCID 0000-0001-9857-4798

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several therapeutic products based on mesenchymal stem cells (MSCs) have been translated into clinical applications. MSCs should undergo in vitro culture before a sufficient quantity can be achieved. Hence, both expansion kinetics and the biological characteristics of derived cells from primary culture are pertinent to their applications. In the present study, MSCs were isolated from rat bone marrow and adipose tissue (designated as bMSCs and aMSCs, respectively) and cells were comparatively analyzed regarding cell morphology, proliferation, colony formation, differentiation potential, and immunophenotype following the long-term subculture. No apparent differences could be noticed concerning the morphology between bMSCs and aMSCs. The long-term subculture made both types of cells smaller, weakened their colony-forming ability, and stimulated the proliferation rate. However, bMSCs demonstrated better proliferation and colony-forming ability than aMSCs. No significant difference was observed about the expression of some immunophenotypes (i.e. CD29+/CD90+/CD34-/CD45-) regardless of cell types or population doublings. Notably, bMSCs, but not aMSCs, maintained the differentiation potential well after the long-term subculture. The present study demonstrates that MSCs derived from different tissues can be well expanded for the long term, although cells display gradually declined self-renewal and differentiation potentials to different extents depending on the tissue origins.

Indexed as

Adipose tissuebone marrowcomparative analysislong-term culturemesenchymal stem cells

Identifiers

PMID30983864
PMCPMC6451846

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.