ArticleThe Saudi dental journal2019
Proposal for a novel murine model of human periodontitis using
Article in The Saudi dental journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed, 9 citations in OpenAlex.
- Mouse periodontitis models using wholeThe Saudi dental journal · 2021Review
- The evaluation of healing effect of triclosan and flurbiprofen-loaded nanogels in experimental periodontitis in rats by morphometric analysis.The Saudi dental journal · 2021Article
- High Fat Diet Dysbiotic Mechanism of Decreased Gingival Blood Flow.Frontiers in physiology · 2021Article
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionPeriodontitis is a chronic disease in humans induced by several pathogens including
methodsTwenty-eight DBA1/BO male mice were placed in four groups: Group A (antibody injection plus gavage), Group B (gavage only), Group C (antibody injection only), and Group D (neither antibody injection nor gavage, control). Between six and eight weeks old, all mice underwent antibiotic administration, and at eight weeks old, were given antibody injection (Groups A and C) and oral
resultsFor histomorphometric analysis, mean distance from the cemento-enamel junction to the alveolar bone crest (CEJ-ABC) and the mean epithelial downgrowth (ED) in μm was statistically significantly highest for Group A (CEJ-ABC 1.49.81 vs. Group B 101.46, Group C 78.74, and Group D 66.23, p < 0.0083; ED 66.76 vs. Group B 25.92, Group C 9.21, and Group D 9.10, p < 0.0083). Morphometric analysis also showed that Group A had a significantly higher mean CEJ-ABC in μm compared to all other groups (265.50 vs. Group B 195.77, Group C 150.33, and Group D 133.93, p < 0.0083). A similar pattern was seen in cell counting, in which Group A had a significantly lower mean count of fibroblasts per 45 × 50 μm field (8.02 vs. Group B 9.56, Group C 12.09, and Group D 11.02, p < 0.0083), and a significantly higher mean count polymorphonuclear leukocytes per 45 × 50 μm (4.59 vs. Group B 1.74, Group C 0.83, and Group D 0.68, p < 0.0083).
conclusionThe results of this study provide proof-of-concept for a mouse model that can be quickly developed for human periodontitis using a type II collagen antibody cocktail injection coupled with oral gavage of
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