Evidence map›Paper›PMID 30983589›Full record

ReviewLancet (London, England)2019

Transition from acute to chronic pain after surgery.

Paul Glare, Karin R Aubrey, Paul S Myles

14 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Lancet (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 14 registered trials, which are not on this map. Cited by 399 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
399citing papers in PubMed, 14 pooled it
72.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04313855 nacompletednot on this mapstarted 2020, after this paper: background citation

Help With Early Detection of Postoperative Neuropathic Pain Using SMS After Ambulatory Surgery

TypeinterventionalSponsorFondation Hôpital Saint-JosephRan2020 to 2022Enrolled306ConditionsChronic Postoperative PainArmsSMS in the early detection of postoperative neuropathic pain
NCT04814992 nacompletednot on this mapstarted 2020, after this paper: background citation

Pre-op CBT to Reduce the Risk for Development of Chronic Post-surgical Pain in Patients Undergoing Total Knee Arthroplasty

TypeinterventionalSponsorUniversity of PennsylvaniaRan2020 to 2023Enrolled54ConditionsChronic Post-Surgical PainArmsComputer-Assisted Preoperative CBT Intervention (PAINTrainer)
NCT05370924 unknown statusnot on this mapstarted 2021, after this paper: background citation

Assessment and Risk Stratification of the Development of Postoperative Persistent Postoperative Pain in Patients Undergoing Orthopedic Surgery

TypeobservationalSponsorA.O.U. Città della Salute e della ScienzaRan2021 to 2024Enrolled600ConditionsOpioid Use, Post Operative Pain, Chronic Pain
NCT05439707 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Effects of Perioperative Transauricular Vagus Nerve Electrical Stimulation on Postoperative Delirium, Postoperative Cognitive Dysfunction and Chronic Postsurgical Pain in Patients Undergoing Arthroplasty.

TypeinterventionalSponsorXuzhou Central HospitalRan2022 to 2024Enrolled600ConditionsPostoperative Cognitive Dysfunction, Postoperative Delirium, Chronic Post Operative PainArmstransaricular vagus nerve stimulation, fake transaricular vagus nerve stimulation
NCT05884021 completednot on this map

Effectiveness of Pain Control and Adverse Reactions After Intravenous PCA in Chinese Population

TypeobservationalSponsorHuazhong University of Science and TechnologyRan2016 to 2022Enrolled40,000ConditionsPostoperative Pain, AcuteArmsPostoperative analgesia
NCT06313320 completednot on this mapstarted 2024, after this paper: background citation

Determination of the Association of Intraoperative Nociception Electroencephalographic Biomarkers and Postoperative Pain

Typeobservational_patient_registrySponsorUniversity of ChileRan2024 to 2026Enrolled57ConditionsPain Postoperative, Nociceptive Pain
NCT06417528 unknown statusnot on this mapstarted 2022, after this paper: background citation

Chronic Postsurgical Pain: Multivariate Prediction Model

TypeobservationalSponsorSocieta Italiana Anestesia Analgesia Rianimazione e Terapia IntensivaRan2022 to 2025Enrolled1,500ConditionsPost Surgical Pain, Post Operative Pain, Postoperative Pain, ChronicArmsChronic Post Surgery Pain (CPSP)
NCT06951802 phase4recruitingnot on this mapstarted 2024, after this paper: background citation

Endometriosis and Pain Treatment by Intraoperative Administration of Low-dose Ketamine A Single-Centre, Prospective, Randomized, Controlled Trial

TypeinterventionalSponsorInsel Gruppe AG, University Hospital BernRan2024 to 2026Enrolled118ConditionsEndometriosisArmsKetamine, Propofol
NCT07246785 phase4terminatednot on this mapstarted 2025, after this paper: background citation

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Trial

TypeinterventionalSponsorPeking University First HospitalRan2025 to 2026Enrolled13ConditionsLaparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous AnalgesiaArmsHigh-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon, Morphine
NCT07259382 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Neuro-Inflammation in Extremity Trauma: Risk Verification in Elbow Trauma: The NERVE Pilot Cohort Study

TypeobservationalSponsorUniversité de MontréalRan2026 to 2030Enrolled60ConditionsElbow Dislocation, Elbow Fractures, Inflammation Biomarkers, TBI Traumatic Brain InjuryArmsBiomarkers evaluation
NCT07525986 phase4recruitingnot on this mapstarted 2026, after this paper: background citation

Efficacy of Anrikefon-based Patient-controlled Intravenous Analgesia for Pain Management After Laparoscopic Surgery: a Randomized, Double-blind, Active-controlled Pilot Tria

TypeinterventionalSponsorPeking University First HospitalRan2026 to 2027Enrolled140ConditionsLaparoscopic Surgery, Visceral Pain, Postoperative, Anrikefon, Patient-controlled Intravenous AnalgesiaArmsHigh-dose anrikefon, Medium-dose anrikefon, Low-dose anrikefon, Morphine
NCT07603271 not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Association Between Early Neuropathic Pain and Chronic Post-Sternotomy Pain After Coronary Artery Bypass Grafting (CABG): A Prospective Observational Study

Typeobservational_patient_registrySponsorInstitute Arnault Tzanck, FranceRan2026 to 2027Enrolled120ConditionsChronic Pain, Postoperative, Sternotomy Pain
NCT07629388 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparative Study Assessing the Efficacy of a Combined Distal Femoral Nerve Block for Postoperative Analgesia Following Total Knee Arthroplasty (TKA)

TypeinterventionalSponsorGCS Ramsay Santé pour l'Enseignement et la RechercheRan2026 to 2027Enrolled240ConditionsPain After Total Knee Arthroplasty, Pain ManagementArmsCombined distal femoral nerve block, Saphenous nerve block alone, Standard perioperative care in both groups
NCT07687966 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Proof-of-concept, Double-blind, Randomized Clinical Study to Evaluate the Safety and Efficacy of CBP-0276 at Doses of 600 mg/Day vs Placebo in Reducing Opioid Use in Pain Management in Adult Patients Undergoing Major Orthopedic Surgery

TypeinterventionalSponsorClarent Biopharma, Inc.Ran2026 to 2026Enrolled80ConditionsHip or Knee ReplacementArmsCBP-0276, Placebo for CBP-0276
3 · Its place in the literature

Who cites it

399 citing papers in PubMed, 14 syntheses or guidelines pooled it, 836 citations in OpenAlex.

  1. Pooled it
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  6. Prolonged opioid use after surgery in children, adolescents, and young adults: a systematic review.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2025
    Pooled it
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  9. Efficacy and safety of acupuncture for pain relief: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
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  14. Erector spinae plane block for postoperative pain.The Cochrane database of systematic reviews · 2024
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339 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Paul GlarePain Management Research Institute, University of Sydney, Sydney, NSW, Australia.
Karin R AubreyPain Management Research Institute, University of Sydney, Sydney, NSW, Australia; Kolling Institute, Royal North Shore Hospital, St Leonards, NSW, Australia.
Paul S MylesDepartment of Anaesthesiology and Perioperative Medicine, Alfred Hospital, Melbourne, VIC. Electronic address: p.myles@alfred.org.au.
University of Sydney · AUThe Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Over the past decade there has been an increasing reliance on strong opioids to treat acute and chronic pain, which has been associated with a rising epidemic of prescription opioid misuse, abuse, and overdose-related deaths. Deaths from prescription opioids have more than quadrupled in the USA since 1999, and this pattern is now occurring globally. Inappropriate opioid prescribing after surgery, particularly after discharge, is a major cause of this problem. Chronic postsurgical pain, occurring in approximately 10% of patients who have surgery, typically begins as acute postoperative pain that is difficult to control, but soon transitions into a persistent pain condition with neuropathic features that are unresponsive to opioids. Research into how and why this transition occurs has led to a stronger appreciation of opioid-induced hyperalgesia, use of more effective and safer opioid-sparing analgesic regimens, and non-pharmacological interventions for pain management. This Series provides an overview of the epidemiology and societal effect, basic science, and current recommendations for managing persistent postsurgical pain. We discuss the advances in the prevention of this transitional pain state, with the aim to promote safer analgesic regimens to better manage patients with acute and chronic pain.

Indexed as

Acute PainAnalgesics, OpioidChronic PainHumansPostoperative PainAnalgesics, Opioid

Identifiers

PMID30983589
OpenAlexW2938546210

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 8 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.