SynthesisJournal of sleep research2019
Morphometric and functional connectivity changes in the brain of patients with obstructive sleep apnea: A meta-analysis.
Synthesis in Journal of sleep research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Reduced cerebral blood flow in obstructive sleep apnea: A meta-analysis of SPECT and MRI studies.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- Sleep disorders and structural alterations in brain regions linked with motivation: a neuroimaging meta-analysis.Scientific reports · 2026Pooled it
- Association between obstructive sleep apnea severity and depression risk: a systematic review and dose-response meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Orexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers.Brain and behavior · 2025Review
- Increased Levels of Plasma Alzheimer's Disease Biomarkers and Their Associations with Brain Structural Changes and Carotid Intima-Media Thickness in Cognitively Normal Obstructive Sleep Apnea Patients.Diagnostics (Basel, Switzerland) · 2022Article
- Sleep Dysfunction and Grey Matter Volume.Current neurology and neuroscience reports · 2022Review
- Assessment of the Effectiveness of Obstructive Sleep Apnea Treatment Using Optical Coherence Tomography to Evaluate Retinal Findings.Journal of clinical medicine · 2022Article
- Electroencephalographic Activity and Cognitive Function in Middle-Aged Patients with Obstructive Sleep Apnea Before and After Continuous Positive Airway Pressure Treatment.Nature and science of sleep · 2021Article
- Insular functional organization during handgrip in females and males with obstructive sleep apnea.PloS one · 2021Article
- Aberrant Hippocampal Network Connectivity Is Associated With Neurocognitive Dysfunction in Patients With Moderate and Severe Obstructive Sleep Apnea.Frontiers in neurology · 2020Article
- Cortical Thickness Mediates the Association Between Self-Reported Pain and Sleep Quality in Community-Dwelling Older Adults.Journal of pain research · 2020Article
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Abstract
Existing evidence for brain morphometric changes and functional connectivity alterations in patients with obstructive sleep apnea is mixed. The current study aimed to meta-analyse the neuroimaging data, and thus synthesize a brain map showing locations with morphometric and functional connectivity differences between patients with obstructive sleep apnea and controls. Published studies to 2018 were retrieved and included into the analysis if they reported such between-group differences using voxel-based morphometry or resting-state functional magnetic resonance imaging, and reported the results in the form of brain coordinates based on whole-brain analysis. Twelve voxel-based morphometry and seven resting-state functional magnetic resonance imaging studies that comprised a total of 1,113 participants fulfilled the inclusion criteria. Compared with healthy controls, patients with obstructive sleep apnea had reduced resting-state connectivity in the right anterior cingulate and larger grey matter volume in the right insula. Patients with obstructive sleep apnea do have morphometric and resting-state connectivity alterations in the brain. These neural correlates may help explain the effects of obstructive sleep apnea on the emotion, cognition and quality of life of patients, and may be used in future for evaluating its treatment outcome.
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Registered trials
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