Evidence map›Paper›PMID 30983028›Full record

ArticlePsychogeriatrics : the official journal of the Japanese Psychogeriatric Society2019

Association of multiple candidate genes with mild cognitive impairment in an elderly Chinese Uygur population in Xinjiang.

Ting Zou, Wei Chen, Xiaohui Zhou, Yali Duan, Xiuru Ying, Guili Liu, Meisheng Zhu, Abuliz Pari, Kader Alimu, Haijun Miao and 4 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Ting ZouDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.ORCID https://orcid.org/0000-0002-6744-4648
Wei ChenDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Xiaohui ZhouDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Yali DuanDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Xiuru YingNingbo Key Lab of Behavior Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
Guili LiuNingbo Key Lab of Behavior Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
Meisheng ZhuDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Abuliz PariDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Kader AlimuDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Haijun MiaoDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Keyim KabinurDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Lei ZhangDepartment of Geriatrics, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China.
Qinwen WangNingbo Key Lab of Behavior Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
Shiwei DuanNingbo Key Lab of Behavior Neuroscience, Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, China.
Xinjiang Medical University · CNNingbo University · CN

Funding

High Technology Research and Development Projects of Xinjiang Province 201517104K. C. Wong Magna Fund in Ningbo UniversityNational Natural Science Foundation of China 81360064Ningbo University
6 · The paper itself

Abstract

backgroundMild cognitive impairment (MCI) is a high-risk factor for Alzheimer's disease (AD). In the present study, we investigated the association of genetic polymorphisms of five genes (8-oxoguanine DNA glycosylase 1 (OGG1), bridging integrator 1 (BIN1), sortilin-related receptor 1 (SORL1), presenilin 2 (PSEN2) and nerve growth factor (NGF)) with MCI risk in a Xinjiang Uygur population. We also tested the relationship between the promoter methylation of genes OGG1 and dihydrolipoamide S-succinyltransferase (DLST) with MCI.

methodsThis study involved 43 MCI patients and 125 controls. Genotyping was done by Sanger sequencing. DNA methylation assays used quantitative methylation-specific polymerase chain reaction.

resultsWe found that polymorphisms of five genes and the methylation of DLST and OGG1 genes were not associated with MCI (P > 0.05). Further subgroup analysis found that DLST hypomethylation was significantly associated with MCI in the carriers of apolipoprotein E (APOE) ε4 (P = 0.042). In the carriers of non-APOE ε4, DLST methylation levels were significantly lower in the male control group than in the female control group (p = 0.04). Meanwhile, among the non-APOE ε4 carriers younger than 75, OGG1 hypermethylation levels were significantly associated with MCI (P = 0.049). DLST methylation in female controls was significantly lower than that in male controls (P = 0.003). According to gender stratification, there was a significant positive correlation of fasting plasma glucose (FBG) and high-density lipoprotein (HDL) with OGG1 methylation in the female controls (FBG: P = 0.024; HDL: P = 0.033). There was a significant inverse correlation between low-density lipoprotein and DLST methylation in male MCI (P = 0.033). There was a significant positive correlation between HDL and DLST methylation levels in the female controls (P = 0.000).

conclusionsThis study was the first to discover that DLST promoter methylation interacted with APOE ε4 and thus affected the pathogenesis of MCI. In addition, OGG1 promoter methylation interacted with several other factors to increase the risk of MCI.

Indexed as

AcyltransferasesAgedAged, 80 and overApolipoprotein E4Asian PeopleAutoantigensCognitive DysfunctionDihydrolipoyllysine-Residue AcetyltransferaseDNA GlycosylasesEthnicityFemaleHumansMaleMitochondrial ProteinsPolymerase Chain ReactionPolymorphism, GeneticAcyltransferasesApolipoprotein E4Autoantigensdihydrolipoamide succinyltransferaseDihydrolipoyllysine-Residue AcetyltransferaseDLAT protein, humanDNA GlycosylasesMitochondrial Proteinsoxoguanine glycosylase 1, humanAPOE ε4DLSTinteractionMCImethylationOGG1

Identifiers

PMID30983028
PMCPMC6899574
OpenAlexW2939606888

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.