ArticleThe Journal of pathology2019
Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.
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Article in The Journal of pathology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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31citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
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Who cites it
31 citing papers in PubMed, 51 citations in OpenAlex.
- Orchestrating the metastatic symphony: the role of extracellular vesicles in the epithelial-mesenchymal transition and pulmonary niche formation of breast cancer.Biological reviews of the Cambridge Philosophical Society · 2026Review
- Redefining the Limits of Nanodevices-Based Drug Delivery Systems: Extracellular Vesicles.Pharmaceutics · 2025Review
- Emerging Strategies for Cargo Loading and Engineering of Extracellular Vesicles for Breast Cancer Treatment.Nanomaterials (Basel, Switzerland) · 2025Review
- Cancer stem cells-derived exosomal TSPAN8 enhances non-stem cancer cells stemness and promotes malignant progression in PDAC.Oncogene · 2025Article
- Unveiling the Involvement of Extracellular Vesicles in Breast Cancer's Organotrophic Metastasis: Molecular Mechanisms and Translational Prospects.International journal of molecular sciences · 2025Review
- Tetraspanins affect membrane structures and the trafficking of molecular partners: what impact on extracellular vesicles?Biochemical Society transactions · 2025Review
- Exosomes and breast cancer angiogenesis; Highlights in intercellular communication.Cancer cell international · 2024Review
- scVAG: Unified single-cell clustering via variational-autoencoder integration with Graph Attention Autoencoder.Heliyon · 2024Article
- New insights into the role of tetraspanin 6, 7, and 8 in physiology and pathology.Cancer medicine · 2024Review
- Tspan protein family: focusing on the occurrence, progression, and treatment of cancer.Cell death discovery · 2024Review
- Review
- Prostate cancer-derived small extracellular vesicle proteins: the hope in diagnosis, prognosis, and therapeutics.Journal of nanobiotechnology · 2023Review
- TSPAN8 regulates EGFR/AKT pathway to enhance metastasis in gastric cancer.Molecular biology reports · 2023Article
- The Tetraspanin Tspan8 Associates with Endothelin Converting Enzyme ECE1 and Regulates Its Activity.Cancers · 2023Article
- The versatile roles of testrapanins in cancer from intracellular signaling to cell-cell communication: cell membrane proteins without ligands.Cell & bioscience · 2023Review
- SARS-CoV-2 infection of airway organoids reveals conserved use of Tetraspanin-8 by Ancestral, Delta, and Omicron variants.Stem cell reports · 2023Article
- Tumor-Derived Exosomes and Their Role in Breast Cancer Metastasis.International journal of molecular sciences · 2022Review
- miR-543 regulates high glucose-induced fibrosis and autophagy in diabetic nephropathy by targeting TSPAN8.BMC nephrology · 2022Article
- Identification of Signature Genes in the PD-1 Relative Gastric Cancer Using a Combined Analysis of Gene Expression and Methylation Data.Journal of oncology · 2022Article
- Article
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Authors and funding
29 authors at 7 institutions in 3 countries.
Maren VoglstaetterInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Andreas R ThomsenDepartment of Radiation Oncology, Medical Center, University of Freiburg, Freiburg im Breisgau, Germany.
Jerome NouvelInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Arend KochInstitute of Neuropathology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Paul JankInstitute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Elena Grueso NavarroInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Tanja Gainey-SchleicherInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Richa KhanduriInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Andrea GroßInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Florian RossnerInstitute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Carina BlaueDFG-Center for Functional Nanostructures, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Clemens M FranzDFG-Center for Functional Nanostructures, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Marina VeilInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Gerhard PuetzInstitute of Clinical Chemistry and Laboratory Medicine, University of Freiburg, Freiburg im Breisgau, Germany.
Andreas HippeDepartment of Dermatology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
Jochen DindorfInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Jubin KashefInstitute for Photon Science and Synchrotron Radiation, Karlsruhe Institute of Technology (KIT), Eggenstein-Leopoldshafen, Germany.
Wilko ThieleMedical Faculty, University of Heidelberg, Mannheim, Germany.
Bernhard HomeyDepartment of Dermatology, Medical Faculty, University of Düsseldorf, Düsseldorf, Germany.
Celine GrecoUMR-S935, Inserm, Université Paris Sud, Université Paris Saclay, Villejuif, France.
Claude BoucheixUMR-S935, Inserm, Université Paris Sud, Université Paris Saclay, Villejuif, France.
Andreas BaurDepartment of Dermatology, University Hospital Erlangen, Erlangen, Germany.
Thalia ErbesDepartment of Gynecology and Obstetrics, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Cornelius F WallerInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Marie FolloDepartment of Medicine I, Medical Center, University of Freiburg, Freiburg, Germany.
Ghamartaj HosseinInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
Christine SersInstitute of Pathology, Charité Universitätsmedizin Berlin, Berlin, Germany.
Jonathan SleemanInstitute of Toxicology and Genetics, Karlsruhe Institute of Technology, Karlsruhe, Germany.
Irina NazarenkoInstitute for Infection Prevention and Hospital Epidemiology; Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID 0000-0002-2633-1161
University of Freiburg · DEKarlsruhe Institute of Technology · DECharité - Universitätsmedizin Berlin · DEHeinrich Heine University Düsseldorf · DEUniversité Paris-Sud · FRFriedrich-Alexander-Universität Erlangen-Nürnberg · DEHeidelberg University · DE
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tspan8 exhibits a functional role in many cancer types including pancreatic, colorectal, oesophagus carcinoma, and melanoma. We present a first study on the expression and function of Tspan8 in breast cancer. Tspan8 protein was present in the majority of human primary breast cancer lesions and metastases in the brain, bone, lung, and liver. In a syngeneic rat breast cancer model, Tspan8
Indexed as
AnimalsBiomarkers, TumorBreast NeoplasmsCadherinsCarcinoma, Ductal, BreastCarcinoma, Intraductal, NoninfiltratingCarcinoma, LobularCell Line, TumorExtracellular VesiclesFemaleHumansNeoplasm MetastasisRatsSignal TransductionTetraspaninsBiomarkers, TumorCadherinsTetraspaninsTSPAN8 protein, humanTspan8 protein, ratbeta-catenin signalling pathwaybreast cancerextracellular vesiclesmesenchymal-epithelial transitionmetastasestetraspaninsthree-dimensional cell cultureTspan8
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