Evidence map›Paper›PMID 30982871›Full record

SynthesisThe American journal of clinical nutrition2019

Infant milk-feeding practices and childhood leukemia: a systematic review.

Darcy Güngör, Perrine Nadaud, Carol Dreibelbis, Concetta C LaPergola, Yat Ping Wong, Nancy Terry, Steve A Abrams, Leila Beker, Tova Jacobovits, Kirsi M Järvinen and 6 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article: "Too Old" and "Too Cold": Discomfort Towards Photographs of Breastfeeding Beyond Infancy and Public Breastfeeding in Nova Scotia, Canada.Journal of human lactation : official journal of International Lactation Consultant Association · 2022
    Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Darcy GüngörPanum Group, Bethesda, MD.
Perrine NadaudPanum Group, Bethesda, MD.
Carol DreibelbisPanum Group, Bethesda, MD.
Concetta C LaPergolaPanum Group, Bethesda, MD.
Yat Ping WongUSDA, Food and Nutrition Service, Alexandria, VA.
Nancy TerryNational Institutes of Health Library, Bethesda, MD.
Steve A AbramsDell Medical School at the University of Texas, Austin, TX.
Leila BekerUS Food and Drug Administration, contractor, College Park, MD.
Tova JacobovitsUS Food and Drug Administration, College Park, MD.
Kirsi M JärvinenUniversity of Rochester Medical Center, Rochester, NY.
Laurie A Nommsen-RiversUniversity of Cincinnati College of Allied Health Sciences, Cincinnati, OH.
Kimberly O O'BrienDivision of Nutritional Sciences, Cornell University, Ithaca, NY.
Emily OkenDivision of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA.
Rafael Pérez-EscamillaDepartment of Social and Behavioral Sciences, Yale School of Public Health, New Haven, CT.
Ekhard E ZieglerDepartment of Pediatrics, The University of Iowa, Iowa City, IA.
Joanne M SpahnUSDA, Food and Nutrition Service, Alexandria, VA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDuring the Pregnancy and Birth to 24 Months Project, the US Departments of Agriculture and Health and Human Services initiated a review of evidence on diet and health in these populations.

objectivesThe aim of these systematic reviews was to examine the relation of 1) never versus ever feeding human milk, 2) shorter versus longer durations of any human milk feeding, 3) shorter versus longer durations of exclusive human milk feeding, and 4) feeding a lower versus higher intensity of human milk to mixed-fed infants with acute childhood leukemia, generally, and acute lymphoblastic leukemia, specifically.

methodsThe Nutrition Evidence Systematic Review team conducted systematic reviews with external experts. We searched CINAHL, Cochrane, Embase, and PubMed for articles published January 1980 to March 2016, dual-screened the results using predetermined criteria, extracted data from and assessed risk of bias for each included study, qualitatively synthesized the evidence, developed conclusion statements, and graded the strength of the evidence.

resultsWe included 24 articles from case-control or retrospective studies. Limited evidence suggests that never feeding human milk versus 1) ever feeding human milk and 2) feeding human milk for durations ≥6 mo are associated with a slightly higher risk of acute childhood leukemia, whereas evidence comparing never feeding human milk with feeding human milk for durations <6 mo is mixed. Limited evidence suggests that, among infants fed human milk, a shorter versus longer duration of human milk feeding is associated with a slightly higher risk of acute childhood leukemia. None of the included articles examined exclusive human milk feeding or the intensity of human milk fed to mixed-fed infants.

conclusionsFeeding human milk for short durations or not at all may be associated with slightly higher acute childhood leukemia risk. The evidence could be strengthened with access to broadly generalizable prospective samples; therefore, we recommend linking surveillance systems that collect infant feeding and childhood cancer data.

Indexed as

DietFeeding BehaviorInfant FormulaLeukemiaMilk, HumanBreast FeedingChildChild HealthHumansInfantInfant, NewbornInfant Nutritional Physiological PhenomenaPrecursor Cell Lymphoblastic Leukemia-Lymphomabreastfeedingbreast milkchildhuman milkinfantleukemiasystematic reviewtoddler

Identifiers

PMID30982871
PMCPMC6500929

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.