SynthesisThe American journal of clinical nutrition2019
Associations of circulating very-long-chain saturated fatty acids and incident type 2 diabetes: a pooled analysis of prospective cohort studies.
Synthesis in The American journal of clinical nutrition, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
37 citing papers in PubMed, 5 syntheses or guidelines pooled it, 74 citations in OpenAlex.
- Application of causal inference methods in individual-participant data meta-analyses in medicine: addressing data handling and reporting gaps with new proposed reporting guidelines.BMC medical research methodology · 2024Pooled it
- Replication and mediation of the association between the metabolome and clinical markers of metabolic health in an adolescent cohort study.Scientific reports · 2023Pooled it
- Lifestyle Factors Associated with Circulating Very Long-Chain Saturated Fatty Acids in Humans: A Systematic Review of Observational Studies.Advances in nutrition (Bethesda, Md.) · 2023Pooled it
- Intake of dietary fats and fatty acids and the incidence of type 2 diabetes: A systematic review and dose-response meta-analysis of prospective observational studies.PLoS medicine · 2020Pooled it
- Pooled it
- Short-term treatment with high dose liraglutide improves lipid and lipoprotein profile and changes hormonal mediators of lipid metabolism in obese patients with no overt type 2 diabetes mellitus: a randomized, placebo-controlled, cross-over, double-blind clinical trial.Cardiovascular diabetology · 2019Trial
- Hyperglycemia and Alteration in Sphingolipids Are Early Mediators of Diabetic Kidney Disease: Role of Elongase 1.American journal of nephrology · 2026Article
- Legacy effects of lifestyle intervention on circulating metabolites in people with impaired glucose tolerance: A cross-sectional analysis of the Da Qing Diabetes Prevention Study.Journal of pharmaceutical analysis · 2026Article
- [The Relationship Between Serum Very Long-chain Saturated Fatty Acids and Chronic Kidney Disease].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026Article
- Very long-chain saturated fatty acids in plasma lipids: association with cardiometabolic risk influenced by lipid interactions.Cardiovascular diabetology · 2025Article
- Article
- Cross-sectional association between the isocaloric replacement of carbohydrates with protein and fat in relation to fat compartments distribution and hepatic lipid content in recent-onset type 1 and type 2 diabetes.Nutrition journal · 2025Article
- Free fatty acids and mortality among adults in the United States: a report from US National Health and Nutrition Examination Survey (NHANES).Nutrition & metabolism · 2024Article
- Article
- Association between the circulating very long-chain saturated fatty acid and cognitive function in older adults: findings from the NHANES.BMC public health · 2024Article
- Association of Circulating Very Long-Chain Saturated Fatty Acids With Cardiovascular Mortality in NHANES 2003-2004, 2011-2012.The Journal of clinical endocrinology and metabolism · 2024Article
- The Associations of Individual and Subclasses of Nonesterified Fatty Acids With Disability, and Mobility Limitation in Older Adults: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Nontargeted Metabolomics Revealed Novel Association Between Serum Metabolites and Incident Acute Coronary Syndrome: A Mendelian Randomization Study.Journal of the American Heart Association · 2023Article
- Metabolite profiles of diabetes mellitus and response to intervention in anti-hyperglycemic drugs.Frontiers in endocrinology · 2023Review
- Circulating Omega-3 and Omega-6 Fatty Acids, Cognitive Decline, and Dementia in Older Adults.Journal of Alzheimer's disease : JAD · 2023Article
Corrections and comments
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Authors and funding
41 authors at 20 institutions in 11 countries.
Funding
Abstract
backgroundSaturated fatty acids (SFAs) of different chain lengths have unique metabolic and biological effects, and a small number of recent studies suggest that higher circulating concentrations of the very-long-chain SFAs (VLSFAs) arachidic acid (20:0), behenic acid (22:0), and lignoceric acid (24:0) are associated with a lower risk of diabetes. Confirmation of these findings in a large and diverse population is needed.
objectiveWe investigated the associations of circulating VLSFAs 20:0, 22:0, and 24:0 with incident type 2 diabetes in prospective studies.
methodsTwelve studies that are part of the Fatty Acids and Outcomes Research Consortium participated in the analysis. Using Cox or logistic regression within studies and an inverse-variance-weighted meta-analysis across studies, we examined the associations of VLSFAs 20:0, 22:0, and 24:0 with incident diabetes among 51,431 participants.
resultsThere were 14,276 cases of incident diabetes across participating studies. Higher circulating concentrations of 20:0, 22:0, and 24:0 were each associated with a lower risk of incident diabetes. Pooling across cohorts, the RR (95% CI) for incident diabetes comparing the 90th percentile to the 10th percentile was 0.78 (0.70, 0.87) for 20:0, 0.84 (0.77, 0.91) for 22:0, and 0.75 (0.69, 0.83) for 24:0 after adjustment for demographic, lifestyle, adiposity, and other health factors. Results were fully attenuated in exploratory models that adjusted for circulating 16:0 and triglycerides.
conclusionsResults from this pooled analysis indicate that higher concentrations of circulating VLSFAs 20:0, 22:0, and 24:0 are each associated with a lower risk of diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.