ArticleThe Journal of veterinary medical science2019
Differences in free amino acid concentrations in milk between Wistar and Wistar Kyoto rats.
Article in The Journal of veterinary medical science, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed, 2 citations in OpenAlex.
- The Greater Impact of Paternal, Compared to Maternal, Hereditary Background on Depressive-Like Behavior in Wistar Kyoto Rats with Different Amino Acid Metabolism in the Pup Brain.International journal of molecular sciences · 2023Article
- Determination of Free Amino Acids in Milk, Colostrum and Plasma of Swine via Liquid Chromatography with Fluorescence and UV Detection.Molecules (Basel, Switzerland) · 2022Article
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3 authors at 1 institution in 1 country.
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Abstract
Wistar Kyoto (WKY) rats, an animal depression model, display abnormal behaviors such as hypoactivity and depression-like behavior compared with Wistar (WIS) rats as a control. A previous study confirmed a dysfunction of amino acid metabolism in the brain of WKY rats compared with that of WIS rats. At the neonatal stage, free amino acids in milk are important nutrients because they act as immediate nutrients for offspring and may affect later health and behavior of the offspring. Therefore, the present study aimed to investigate free amino acid concentrations in milk and the relationships between free amino acid concentrations in milk and plasma in WIS and WKY rats. The concentrations of ten of the determined free amino acids in milk were significantly higher, but only L-methionine was significantly lower, in WKY rats. Six free amino acids had significantly higher concentrations in colostrum and two free amino acids had higher concentrations in matured milk. Free amino acid concentrations in plasma changed by both genetic background and lactation stage; however, the patterns of change in most free amino acid concentrations except for taurine in plasma were similar between WIS and WKY rats. The transport ratio of free amino acids from plasma to milk was not similar among the free amino acids tested, and each free amino acid was influenced by the genetic background and/or the type of milk.
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