ArticleDevelopmental cell2019
Loss of Sirtuin 1 Alters the Secretome of Breast Cancer Cells by Impairing Lysosomal Integrity.
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In one paragraph
Article in Developmental cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 97 papers.
0numbers the graph read from it
0cells of the map it votes in
97citing papers in PubMed
11.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
97 citing papers in PubMed, 152 citations in OpenAlex.
- SIRT1 Promotes Breast Cancer Stem Cell-Associated Properties and Represents a Potential Therapeutic Target.International journal of molecular sciences · 2026Article
- V-ATPase-targeted siRNA library screening reveals ATP6V1A negatively regulates UVB-induced keratinocyte senescence.Biology direct · 2026Article
- Dysregulation of the TFEB-ATP6V0C axis in microglia exacerbates α-synuclein pathology through impaired lysosomal acidification in Parkinson's disease.Cell death and differentiation · 2026Article
- Subtype-specific sirtuin expression signatures link mitochondrial-epigenetic networks to breast cancer survival.GeroScience · 2026Article
- MYC-driven gliosis impairs neuron-glia communication in amyotrophic lateral sclerosis.Brain : a journal of neurology · 2026Article
- All the Way: A Decade of SIRT1 in Breast Cancer.Biomedicines · 2026Review
- Extracellular vesicle-mediated preconditioning of osteoblasts by ER+ breast cancer cells: implications for the bone metastatic niche.Frontiers in pharmacology · 2026Article
- Review
- Modulation of Endoplasmic Reticulum Stress by Selected Polyphenols fromPlants (Basel, Switzerland) · 2025Review
- Epidrug screening identifies type I PRMT inhibitors as modulators of lysosomal exocytosis and drug sensitivity in cancers.Cell death & disease · 2025Article
- Mechanical regulation of extracellular vesicle activity during tumour progression.Nature biomedical engineering · 2025Review
- Histone acetylation modulators in breast cancer.Breast cancer research : BCR · 2025Review
- Menin maintains lysosomal and mitochondrial homeostasis through epigenetic mechanisms in lung cancer.Cell death & disease · 2025Article
- Delactylase effects of SIRT1 on a positive feedback loop involving the H19-glycolysis-histone lactylation in gastric cancer.Oncogene · 2025Article
- Extracellular vesicles in tumor immunity: mechanisms and novel insights.Molecular cancer · 2025Review
- Breaking boundaries: role of the brain barriers in metastatic process.Fluids and barriers of the CNS · 2025Review
- Development of a Novel Lysosomal Gene-based Prognostic Panel and Uncovering EIF4EBP1 as a Biomarker for Breast Cancer.Current genomics · 2025Article
- Response of MDA-MB231 cells to cisplatin and paclitaxel - viability, migration and gene expression estimation in mono- and co-culture with macrophages.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025Article
- Resolving the two-body problem: A postulated role for the V0 sector of the V0V1-ATPase in exosome biogenesis and multivesicular body fate.Molecular biology of the cell · 2025Article
- Cigarette smoke exposure triggers dendritic cell-derived exosome-mediated Th17 and Treg polarization through an autophagy- and necroptosis-associated SIRT1-dependent mechanism in vitro.Frontiers in immunology · 2025Article
37 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Arash LatifkarDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Lu LingNancy E. and Peter C. Meinig School of Biomedical Engineering, Ithaca, NY 14853, USA; Kavli Institute at Cornell for Nanoscale Science Cornell University, Ithaca, NY 14853, USA.
Amrit HingoraniDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
Eric JohansenDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
Amdiel ClementDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
Xiaoyu ZhangDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
John HartmanSibley School of Mechanical and Aerospace Engineering, Cornell University, Ithaca, NY 14853, USA.
Claudia FischbachNancy E. and Peter C. Meinig School of Biomedical Engineering, Ithaca, NY 14853, USA; Kavli Institute at Cornell for Nanoscale Science Cornell University, Ithaca, NY 14853, USA.
Hening LinDepartment of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA; Howard Hughes Medical Institute, Cornell University, Ithaca, NY 14853, USA.
Richard A CerioneDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA. Electronic address: rac1@cornell.edu.
Marc A AntonyakDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
Cornell University · USIthaca College · US
Funding
Training and OutreachP30GM124166 · NIGMS · CORNELL UNIVERSITY · PI RICHARD A. CERIONE · 2019 to 2026
$28.3MProject 3: Physical and Metabolic Constraints of Cancer Cell InvasionU54CA210184 · NCI · CORNELL UNIVERSITY · PI SCHAFFER, CHRIS B · 2016 to 2020
$10.2MThe unique roles of the GTP-binding/protein crosslinking enzyme transglutaminase-2 and signaling partners in aggressive cancersR01CA201402 · NCI · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2016 to 2024
$4.3MNew frontiers in extracellular signalingR35GM122575 · NIGMS · CORNELL UNIVERSITY · PI CERIONE, RICHARD A. · 2017 to 2021
$3.0MThe role of lysosomal deregulation in cancer progressionF99CA234921 · NCI · CORNELL UNIVERSITY · PI LATIFKAR, ARASH · 2018 to 2019
$84kNCI NIH HHS F99 CA234921NCI NIH HHS R01 CA201402NCI NIH HHS U54 CA210184NIGMS NIH HHS P30 GM124166NIGMS NIH HHS R35 GM122575
Abstract
The NAD
Indexed as
Breast NeoplasmsCell Line, TumorCell SurvivalExosomesFemaleHomeostasisHumansLysosomesMultivesicular BodiesNeoplasm InvasivenessSirtuin 1Vacuolar Proton-Translocating ATPasesSIRT1 protein, humanSirtuin 1Vacuolar Proton-Translocating ATPasescancercathepsindeacetylationexosomesextracellular vesicleslysosomemulti-vesicular bodysecretomesirtuinvacuolar-type H(+) ATPase
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Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.