ArticleCurrent biology : CB2019
Opposing Influence of Sensory and Motor Cortical Input on Striatal Circuitry and Choice Behavior.
Article in Current biology : CB, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Learning shapes neural codes for sensory-motor integration in the tail of the striatum.bioRxiv : the preprint server for biology · 2026Article
- Neuropathic pain drives time-dependent reorganization of corticostriatal circuits.bioRxiv : the preprint server for biology · 2025Article
- Role of posterior medial thalamus in the modulation of striatal circuitry and choice behavior.eLife · 2025Article
- Article
- Stimulus selection enhances value-modulated somatosensory processing in the superior colliculus.PLoS biology · 2025Article
- The 6-OHDA Parkinson's Disease Mouse Model Shows Deficits in Sensory Behavior.bioRxiv : the preprint server for biology · 2025Article
- Synaptic integration of somatosensory and motor cortical inputs onto spiny projection neurons of mice caudoputamen.The European journal of neuroscience · 2024Article
- Cell-Type Specific Connectivity of Whisker-Related Sensory and Motor Cortical Input to Dorsal Striatum.eNeuro · 2024Article
- The Interactions of Temporal and Sensory Representations in the Basal Ganglia.Advances in experimental medicine and biology · 2024Review
- Related neural networks underlie suppression of emotion, memory, motor processes as identified by data-driven analysis.BMC neuroscience · 2023Article
- Dorsolateral Striatum is a Bottleneck for Responding to Task-Relevant Stimuli in a Learned Whisker Detection Task in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Cortical-subcortical interactions in goal-directed behavior.Physiological reviews · 2023Review
- Preserved Motility after Neonatal Dopaminergic Lesion Relates to Hyperexcitability of Direct Pathway Medium Spiny Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Convergence of forepaw somatosensory and motor cortical projections in the striatum, claustrum, thalamus, and pontine nuclei of cats.Brain structure & function · 2022Article
- Multimodal Sensorimotor Integration of Visual and Kinaesthetic Afferents Modulates Motor Circuits in Humans.Brain sciences · 2021Article
- Context-Dependent Sensory Processing across Primary and Secondary Somatosensory Cortex.Neuron · 2020Article
- The Functional Organization of Cortical and Thalamic Inputs onto Five Types of Striatal Neurons Is Determined by Source and Target Cell Identities.Cell reports · 2020Article
- Converging sensory and motor cortical inputs onto the same striatal neurons: An in vivo intracellular investigation.PloS one · 2020Article
- Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The striatum is the main input nucleus of the basal ganglia and is a key site of sensorimotor integration. While the striatum receives extensive excitatory afferents from the cerebral cortex, the influence of different cortical areas on striatal circuitry and behavior is unknown. Here, we find that corticostriatal inputs from whisker-related primary somatosensory (S1) and motor (M1) cortex differentially innervate projection neurons and interneurons in the dorsal striatum and exert opposing effects on sensory-guided behavior. Optogenetic stimulation of S1-corticostriatal afferents in ex vivo recordings produced larger postsynaptic potentials in striatal parvalbumin (PV)-expressing interneurons than D1- or D2-expressing spiny projection neurons (SPNs), an effect not observed for M1-corticostriatal afferents. Critically, in vivo optogenetic stimulation of S1-corticostriatal afferents produced task-specific behavioral inhibition, which was bidirectionally modulated by striatal PV interneurons. Optogenetic stimulation of M1 afferents produced the opposite behavioral effect. Thus, our results suggest opposing roles for sensory and motor cortex in behavioral choice via distinct influences on striatal circuitry.
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Registered trials
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