Evidence map›Paper›PMID 30982643›Full record

ArticleSchizophrenia research2019

Normal categorical perception to syllable-like stimuli in long term and in first episode schizophrenia.

Sarah M Haigh, Rebecca M Laher, Timothy K Murphy, Brian A Coffman, Kayla L Ward, Justin R Leiter-McBeth, Lori L Holt, Dean F Salisbury

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Schizophrenia research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Sarah M HaighDepartment of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA; Department of Psychology and Center for Integrative Neuroscience, University of Nevada, Reno, Mack Social Science, 1664 N Virginia Street, Reno, NA, 89557, USA.
Rebecca M LaherDepartment of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA.
Timothy K MurphyDepartment of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA; Department of Psychology, Carnegie Mellon University, Baker Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA.
Brian A CoffmanDepartment of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA.
Kayla L WardDepartment of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA.
Justin R Leiter-McBethDepartment of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA.
Lori L HoltDepartment of Psychology, Carnegie Mellon University, Baker Hall, 5000 Forbes Avenue, Pittsburgh, PA 15213, USA.
Dean F SalisburyDepartment of Psychiatry, University of Pittsburgh, Suite 420, 3501 Forbes Avenue, Pittsburgh, PA 15213, USA. Electronic address: salisburyd@upmc.edu.

Funding

UNIVERSITY OF PITTSBURGH CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE: BPCAUL1RR024153 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2006 to 2011
$73.9M
Statistics and Data Management CoreP50MH103204 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI OLSON, CARL ROGER · 2014 to 2018
$10.8M
Mismatch Negativity and Complex Second-Order Sensory Memory in SchizophreniaR01MH094328 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SALISBURY, DEAN F · 2012 to 2016
$1.9M
NCRR NIH HHS UL1 RR024153NIMH NIH HHS P50 MH103204NIMH NIH HHS R01 MH094328
6 · The paper itself

Abstract

Schizophrenia is associated with deficits in language processing that are evident even at first-episode. However, there is debate as to how early in the processing stream the linguistic deficits appear. We measured categorical processing of artificial syllables that varied in voice-onset time (VOT), and how sensory biasing impacts categorical perception. VOT varied in 5 ms increments from 0 ms (strong /ba/) to 40 ms (strong /pa/). Participants chose whether a syllable sounded more like /ba/ or /pa/. Twenty-two individuals with long-term schizophrenia (Sz) were compared to 21 controls (HCSz), and 17 individuals at their first-episode of schizophrenia (FE) were compared to 19 controls (HCFE). There were three conditions: equiprobable - each syllable had an equal probability of being presented; /ba/-biased - 0 ms VOT (strong /ba/) presented 70% of the time; /pa/-biased - 40 ms VOT (strong /pa/) presented 70% of the time. All groups showed categorical perception and category shifts during biased conditions. Sz and FE were statistically indistinguishable from controls in the point of categorical shift, slope of their response function, and the VOT needed to reliably perceive /pa/. Together, this suggests intact ability to map acoustic stimuli to phonetic categories when based on timing differences in voiced information, both early and late in the disease.

Indexed as

AdultFemaleHumansMaleMiddle AgedPhoneticsPsychotic DisordersSchizophreniaSpeech PerceptionTime FactorsCategorical perceptionFirst episodeSchizophreniaSyllableVoice onset time

Identifiers

PMID30982643
PMCPMC6607915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.